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OCULAR ONCOLOGY. MICHAEL E GIBLIN FRANZCO. OSSN. Ocular surface squamous neoplasia Encompasses conjunctival/corneal intraepithelial neoplasia (CIN) Squamous conjunctival dysplasia Carcinoma in situ Invasive squamous cell carcinoma (SCC). Squamous cell carcinoma. Extensive
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OCULAR ONCOLOGY MICHAEL E GIBLIN FRANZCO
OSSN • Ocular surface squamous neoplasia • Encompasses conjunctival/corneal intraepithelial neoplasia (CIN) • Squamous conjunctival dysplasia • Carcinoma in situ • Invasive squamous cell carcinoma (SCC)
Squamous cell carcinoma • Extensive • Ill defined edges • Vascularised • Corneal involvement
Conjunctival melanoma • Primary aquired conjunctival melanosis (PAM) • Preexisting conjunctival naevus • De novo
PAM • Primary acquired conjunctival melanosis • Biopsy if: • Growth • Nodule formation • Vascularity
Rx Conjunctival SCC / Melanoma • Excision / cryotherapy to cut conjunctival margin • Topical Mitomycin C • Episcleral plaque radiotherapy if recurrence
Congenital hypertrophy of the retinal pigment epithelium (CHRPE)
Melanocytic tumours of the posterior uvea • Naevus • Melanoma
Choroidal naevus Drusen Fibrous metaplasia of RPE
Uveal melanoma treatment • Observation • Tumours < 2mm thick
Symptoms • Thickness > 2mm • Orange pigment (lipofuscin) • Growth • Subretinal fluid • Peripapillary location
Uveal melanoma treatment • Observation • Transpupillary laser thermotherapy (TTT) • Thickness < 3.5mm • Posterior pole
Uveal melanoma treatment • Observation • TTT • Local resection Base < 10mm • Anterior to • equator
Uveal melanoma treatment • Observation • TTT • Localresection • Radioactive plaque therapy • Base <15mm Thickness < 8mm
Iodine 125 Ruthenium 106
Uveal melanoma treatment • Observation • TTT • Localresection • Radioactiveplaquetherapy • Proton beam/helium ion irradiation • Gamma knife therapy
Uveal melanoma treatment • Observation • TTT • Localresection • Radioactiveplaquetherapy • Protonbeam/helium ion irradiation • Gamma knife therapy • Enucleation • Base > 15mm
Metastatic tumours • Breast / lung carcinoma • Amelanotic • Multifocal • Choroidal • Treat only if sight affected
Amelanotic Multifocal Choroidal Posterior to equator
M AG ICMI KETHE MEDICI NEMAN