1 / 17

Trichomonas Vaginalis ( 阴道毛滴虫 )

Trichomonas Vaginalis ( 阴道毛滴虫 ). Inhabit --- Female : vagina, urethra --- Trichomonas vaginitis , Trichomonas urethritis. --- Male : urethra, prostate gland --- Trichomonas urethritis. 乒乓 (ping-pong) 感染. 4 anterior flagella. 1. Morphology.

tekli
Télécharger la présentation

Trichomonas Vaginalis ( 阴道毛滴虫 )

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Trichomonas Vaginalis (阴道毛滴虫) Inhabit --- Female: vagina, urethra --- Trichomonas vaginitis, Trichomonas urethritis --- Male: urethra, prostate gland --- Trichomonas urethritis

  2. 乒乓(ping-pong)感染

  3. 4 anterior flagella 1. Morphology Trophozoite 1 nucleus colorless pyriform or oval 1030μm×1015μm undulating membrane (1 posterior flagellum) axostyle

  4. Trophozoites – Gimsa stain

  5. Four anterior flagella The single lateral flagellum (the undulating membrane(波动膜）

  6. 2. Life cycle (One host, one stage)

  7. Inhabiting sites： Infective stage： Mode of infection： Female--vagina, urethra Male--urethra, prostate gland Trophozoit (Multiplies by longitudinal binary fission) Direct contact： sexual intercourse Contact Indirect contact： sharing the hygiene utilities

  8. 3. Pathogenesis (1)Pathogenic mechanism • 1）Contact-dependent cytopathic effect： • surface proteins： responsible for cell adherence • cell-detaching factor：causes detachment of the • host’s cell

  9. Self-cleaning function of vagina: vaginal epithelium （rich in glycogen） Control the growth and reproduction of parasites Bacilli（杆菌） (normal flora) convert lactic acid Women Under Normal condition The viginal Secretions: pH3.8-4.4 Non-pathogenic

  10. Women under some conditions (pregnancy, after Menses, etc. Reduction in acidity of vagina (of pH rising above 5.0) If T.v infects the women at this time The trophozoites multiplies rapidly Vaginitis Because of the T.v competitively take advantage of the glucogen, the pH of the vagina rises up higher and is therefore advantage of growth of other pathogenic bacteria.

  11. (2) Pathologic changes • Reddened vaginal mucosa can be seen. • In severe cases, petechial hemorrhages is present. (3) Clinical manifestation 1）Vaginitis • white, frothy discharge (creamy white in color, full of bacteria )，foul-smelling • Itching, Vaginal burning, • The vaginal secretions are liquid, greenish or yellow Frequency of urination(撒尿), Dysuria

  12. 2) In male： • Usually asymptomatic • Frequency of urination • Dysuria • Prostate may be enlarged , Prostatitis

  13. 4. Diagnosis (1)Parasitic diagnosis： 1） Direct smear ① Saline smear(生理盐水涂片) ② Staining specimen： Discharge from posterior vaginal fornix, Urine, Secretion of prostate gland 2）Cultivation：specimen above，37℃，48h， microscopic exam (2)Immunologic test：Ag detection (3)DNA probe

  14. 5. Epidemiology (1)Didtribution： world wide, especially in female at the age group of 20～40, average prevalence is 28％. In America：2 ~ 3million infective cases per year In China：wide spread

  15. (2)Transmission 1）The source of infection：patient、carrier （ including male） 2）The route of infection： ①Direct contact：sexual intercourse (STD) ②Indirect contact：public bathtub , towels, toilet seats, bathing suit • The trophozoites have strong resistance to the outside • environment : The trophozoits can survive for 14h ~ 20h in semi-drying environment, for 7h at -10 ℃ ， for 102h at 40 ℃, for 30 min on toilet seat, for 45h ~ 150h in soap-water

  16. 6. Treatment and Prevention (1) Control of infective sources：screening detection of patients and carriers • Oral administration：Metronidazole, Tinidazole Remark: sexual partners must be treated at the same time (2) Block the routes of transmission：Improve the public swimming pool, toilet, etc， (3) Protection of population: Keep good personal hygiene， Safer Sex

More Related