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An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application

An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application. Motivation: PoC biosensing requires high sensitivity, high portability, low cost and low power . Applications: Medical Diagnosis (epidemic disease control…)

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An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application

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  1. An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application • Motivation:PoC biosensing requires high sensitivity, high portability, low cost and low power. • Applications: • Medical Diagnosis (epidemic disease control…) • Environmental Monitoring (pollution…) • Bio-warfare (lethal agents detection…) • Background: • Optical microarray  bulky and expensive optics. • Existing magnetic sensors  external B-field and costly post-processing. • Our Approach: Frequency shift magnetic-based biosensor  No magnetic biasing and completely CMOS compatible An Ideal PoC Sensor

  2. Sensor Mechanism and System Architecture • Mechanism: Frequency Shift of the On-chip LC Oscillator • Sensitivity Improving: Diff. Sensing and On-chip Temp Ctrl  σ∆f/f0=0.13ppm • Architecture: Down-Conversion and 8-Cell Array • Sensor SNR Optimization • DAC Tools: HFSS, Maxwell, Matlab / Ephysics / Spectre, UltraSim, Virtuso, Calibre Sensor Inductor Geometry

  3. Chip Microphotograph and Measurement Results • Summary: 2.95mm x 2.56mm in 130nm CMOS with 165mW • Magnetic Bead Sensing: A single 1μm bead • Actual DNA Sensing: 1n-Molar magnetically labeled DNA  The Most Sensitive CMOS Magnetic Biosensor

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