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Understanding TLR Pathways in Inflammation and Immune Response

This overview explores the role of Toll-like receptors (TLRs) and associated proteins in immune response and inflammation. Key components like MyD88, MAL, and IRAs interact with various stimuli, including lipopolysaccharides (LPS) and flagellin, leading to the activation of pro-inflammatory cytokines such as IL-1β. The significance of the NALP3 inflammasome, its assembly with ASC and caspase-1, and the downstream effects on NFkB activation are discussed. The interplay between these pathways highlights their role in recognizing danger signals, contributing to inflammation and immune defense.

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Understanding TLR Pathways in Inflammation and Immune Response

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  1. TLR 2 TLR 1 TLR 6 TLR 4 TLR 5 MD2 CD36 MyD88 MAL MyD88 CD14 IkBα IKKα IKKγ IKKβ MAL MyD88 p65 p50 IRAK4 IRAK1 TRAF6 Lipoproteins ECM components LPS Flagellin Cholesterol crystals IL1β IL1β NALP3 nucleus pro IL1β CARD ASC CASPASE 1 NFkB INFLAMMASOME cytosol

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