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Improved Survival Rate with TMZ Chemotherapy: Stupp Trial Analysis

Stupp Trial analysis reveals enhanced survival outcomes with TMZ chemotherapy for patients with MGMT gene alteration. Results demonstrate significant impact on overall survival rates, validating the efficacy of combined treatment.

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Improved Survival Rate with TMZ Chemotherapy: Stupp Trial Analysis

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  1. Stupp Trial: Improved survival with TMZ Chemotherapy 100 90 80 RT + TMZ 70 RT 60 Probability of OS (%) 50 40 30 20 10 0 6 12 18 24 30 36 42 Months No. at Risk RT 286 240 144 59 23 2 0 RT+TMZ 257 216 174 109 57 27 4 HR 0.63 (95% Cl, 0.52 to 0.75; p<0.001) Adapted from Scrive et al. ASTRO 2007

  2. Long-term Survival Adapted from Mirimanoff et al. ASTRO 2007.

  3. MGMT Gene Status: Survival at Four Years Adapted from Mirimanoff et al. ASTRO 2007.

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