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Exploring Sex and Gender Differences in Nutrigenomics Research: Implications for Health

This review by Nicolien Wieringa examines the influence of sex and gender on nutrigenomics, a relatively young field with high hopes for disease prevention. It highlights research gaps and emphasizes the need for a gender perspective in formulating research questions. Key topics include the interaction between nutrition and the menstrual cycle, the impact of sex hormones on disease susceptibility, and the role of diet in conditions like osteoporosis and genetic disorders affecting women. The need for more focused studies on female models is critical for advancing individualized dietary recommendations.

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Exploring Sex and Gender Differences in Nutrigenomics Research: Implications for Health

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Presentation Transcript

  1. GenderBasic meeting Comments on Nutrigenomics review of Jose Ordovas by Nicolien Wieringa

  2. Nutrigenomics • Relatively young research field • High expectations for applications in disease prevention

  3. Sex differences? • Yes!

  4. A tiny search • How do sex/gender play a role in nutrigenomics research? • PubMed search (not much…..) • Role of sex/gender in Dutch Nutrigenomics Consortium

  5. Gender perspective in research • Defining research questions taking into account sex/gender differences • Research models • Context of application

  6. Basic research questions • What interactions between nutrition and the menstrual cycle play a role in health and disease? • Since many chronic diseases in women occur after menopause, how do sex hormones interact in the relationships between nutrition and disease susceptibility?

  7. continued • What effects do dietary habits have on the development of osteoporosis in women and which role do genetic factors play? • What is the role of nutrition in diseases with a genetic component that frequently occur in women, e.g. migraine, depression, astma?

  8. continued • How does nutrition interact with genes in the development of eating disorders that occur frequently in girls and women, for example anorexia nervosa? • What is the genetic basis for low levels of folic acid in women who therefore have a high risk of conceiving children with neurological malformations?

  9. Relevant animal models • Available? • “Very little is known about the female mouse” • Developments needed!

  10. Context of application • Development of “individualized diets” • New ways of constructing populations • News avenues for gender bias?

  11. Context nutrigenomics research • Cardiovascular disease, obesity: lifestyle diseases • Focus on biomedical and socio-cultural causes • Balance needed in research policy

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