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Introduction to CNS pharmacology

Introduction to CNS pharmacology. By S.Bohlooli, PhD School of medicine, Ardabil University of Medical Sciences. Ion channels & neurotransmitter receptors. Voltage gated channels Ligand gated channels Ionotropic receptors Metabotropic receptors Membrane delimited

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Introduction to CNS pharmacology

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  1. Introduction to CNS pharmacology By S.Bohlooli, PhD School of medicine, Ardabil University of Medical Sciences

  2. Ion channels & neurotransmitter receptors • Voltage gated channels • Ligand gated channels • Ionotropic receptors • Metabotropic receptors • Membrane delimited • Diffusible second messenger

  3. Ion channels

  4. Metabotropic receptors

  5. 3D structure of Nicotine receptor

  6. The synapse & synaptic potentials • Excitatory • Excitatory post-synaptic potential (EPSP) • Ionotropic receptor • Inhibitory • Inhibitory post-synaptic potential (IPSP) • Presynaptic inhibition

  7. Some Toxins Used to Characterize Ion Channels

  8. Excitatory postsynaptic potentials (EPSP)

  9. Interaction of excitatory and inhibitory synapses

  10. Site of drug action

  11. Identification of central neurotransmitters • More difficult for CNS • Anatomic complexity • Limitation of available techniques

  12. Criteria for neurotransmitter identification • Localization • Microcytochemical • immonocytochemical • Release • Simulation of Brain slices • Calcium dependency of release • Synaptic mimicry • Microiontophoresis • Physiological view • Pharmacological view

  13. Cellular organization of the brain • Hierarchical systems • Sensory perception, motor control • Phasic information, delineated pathways • Two types of neurons • Projection or relay • Local circuit neurons • Limited number of transmitters • Nonspecific or diffuse neuronal systems • Affecting global function of CNS • Small number of neurons, projections to wide area of CNS

  14. Pathways

  15. Central neurotransmitters • Amino acids • Neutral amino acids • Acidic amino acids • Acetylcholine • Monoamines • Dopamine • Norepinephrine • 5-hydroxytryptamine • Peptides • Nitric oxide • endocananbiniods

  16. Summary of Neurotransmitter Pharmacology in the Central Nervous System

  17. Summary of Neurotransmitter Pharmacology in the Central Nervous System

  18. Summary of Neurotransmitter Pharmacology in the Central Nervous System

  19. Summary of Neurotransmitter Pharmacology in the Central Nervous System

  20. Schematic diagram of a glutamate synapse

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