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Understanding Excitatory Synapses and Long-Term Potentiation Mechanisms

This chapter delves into the intricate workings of excitatory synapses, detailing the signaling cascades and receptor types involved in synaptic transmission. It highlights the roles of ionotropic receptors and the dynamics of glutamate receptors. By examining the agonistic and antagonistic actions of different drugs on these receptors, the text elucidates how NMDA and AMPA receptor interactions facilitate long-term potentiation (LTP). The chapter presents schematic representations and key figures for better comprehension of synaptic strength changes and the induction of LTP.

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Understanding Excitatory Synapses and Long-Term Potentiation Mechanisms

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Presentation Transcript

  1. Chapter 3 Opener

  2. Figure 3.1 A schematic representation of an excitatory synapse

  3. Figure 3.1 A schematic representation of an excitatory synapse (Part 1)

  4. Figure 3.1 A schematic representation of an excitatory synapse (Part 2)

  5. Figure 3.2 The signaling cascade

  6. Figure 3.3 Kinases are composed of an inhibitory and a catalytic domain

  7. Figure 3.4 Ionotropic receptors

  8. Figure 3.4 Ionotropic receptors (Part 1)

  9. Figure 3.4 Ionotropic receptors (Part 2)

  10. Figure 3.5 There are three types of glutamate receptors

  11. Figure 3.6 The agonistic and antagonistic actions of drugs

  12. In-Text Art, Ch. 3, p. 50 Graham Collingridge

  13. Figure 3.7 APV, an NMDA receptor antagonist, prevents the induction of LTP but has no effect on its expression

  14. Figure 3.8 The NMDA receptor

  15. Figure 3.8 The NMDA receptor (Part 1)

  16. Figure 3.8 The NMDA receptor (Part 2)

  17. In-Text Art, Ch. 3, p. 53 Gary Lynch

  18. Figure 3.9 AMPA receptors traffic into and out of dendritic spines

  19. Figure 3.10 The number of theta-burst stimuli (TBS) determines the duration of LTP

  20. Figure 3.11 A sequence of events leading to the induction of LTP

  21. Figure 3.12 Changes in synaptic strength that support LTP

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