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Britton Chance: The Development of In Vivo MRS

Britton Chance: The Development of In Vivo MRS. Mitchell Schnall MD, PhD. Metabolism as a basis for understanding and curing disease. Warm Ischemia. 4 degrees C. 75 second spectrum. Exercising in the NMR magnet.

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Britton Chance: The Development of In Vivo MRS

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  1. Britton Chance: The Development of In Vivo MRS Mitchell Schnall MD, PhD

  2. Metabolism as a basis for understanding and curing disease

  3. Warm Ischemia 4 degrees C

  4. 75 second spectrum

  5. Exercising in the NMR magnet

  6. The Transfer function: “Furthermore, the slope and extentof the linear portion of Fig. 4 are pivotal in the identification of normal and pathological functions of the limb.” Figure 4

  7. Assuming ADP control and Michaelis- Menten kinetics assuming a constant pH of 7.1, a temperature of 370C, a 1.0-mM magnesium concentration, and a 5-mM ATP concentration giving Kobs, = 132 (1) and Km ADP = 20 AM (19, 24). Vmax of 52 J/min and a Km of 0.65 ± 0.06.

  8. PFK

  9. Recovery kinetics as a Biomarker PVD patient PFK deficient

  10. Vitamin C Vitamin K3

  11. Detecting Treatment Response Patient prior to (A) and after (B) therapy Normal Subject 10 5 0 Min

  12. 1985

  13. BC’s Contribution to MRS • Established feasibility to real time measurement of metabolites in perfused organs, intact animal models, and humans • Developed a mechanistic approach to interpretation of spectral data for the purpose of clinical diagnostics • Developed a strategy of using MRS as a pharmaco-dynamic marker of treatment effect • Established the role of PME (choline in the proton spectrum) as an important marker of malignancy • Inspired the development of methodology to support further application of MRS • Surface coils • Chemical shift imaging • Rotating frame imaging • Multinuclear spectroscopy • Hadamard spectroscopy • NMR pulse design methodology • Multimodality Optical-MR spectroscopy

  14. Brit’s own acknowledgements

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