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Phenotype Databases: Comprehensive Resource for RNAi Screening

Access over 91,000 dsRNAs and 6,100 phenotype records from 29 large-scale studies in cultured Drosophila cells. Explore phenotypic data archives, experimental methods, and results from C. elegans analyses. Discover genotype-phenotype interactions in a genotype/phenotype database. Efficiently manage diverse genetic backgrounds and experimental treatments with specialized tools.

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Phenotype Databases: Comprehensive Resource for RNAi Screening

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  1. Phenotype Databases GenomeRNAi Phenotypes from systematic RNAi screens in cultured Drosophila cells. Currently 91,000 dsRNAs, 6100 phenotype records from 29 large-scale studies. rnai.dkfz.de (DKFZ/Boutros) NAR 2007 D492-7 RNAiDB Archival, distribution and analysis of phenotypic data from large-scale RNAi analyses inC. elegans. Compendium of publicly available data, information on experimental methods and phenotypic results, including raw data in the form of images and time-lapse movies. www. rnai.org (F. Piano, NYU) NAR 2004 D406-10 dbGaP Database of Genotype and Phenotype. Archive and distribute results of studies of interaction of genotype and phenotype: genome-wide association studies, medical sequencing, molecular diagnostic assays, association between genotype and non-clinical traits. Driven by the advent of high-throughput, cost-effective methods for genotyping and sequencing. NCBI PhenomicDB Genotype/phenotype database that merges public data (OMIM, MGI, WormBase, FlyBase, CYGD, ZFIN, and MatDB) from multiple species www.phenomicdb.de (Metalife, small company in the Black Forest)

  2. OME Dundee, NIA Baltimore, MIT and LOCI. Goal: to produce a software tool that can manage any type of microscope image data: 5D Metadata

  3. Phenotype-experiments Phenotype However: There are many different genetic backgrounds (e.g. specific KOs) and experimental treatments (e.g. co-RNAi, conditioning of growth media). Finding a generic ontology will be a big task Molecular Probe (siRNA, compund, …) Numeric or categoric scores

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