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Integrative PBPK Model for Blood Propofol Concentration Over Time After Induction
DESCRIPTION
This study presents an advanced Physiologically-Based Pharmacokinetic (PBPK) model that accurately predicts blood concentrations of Propofol (mg/ml) following induction. The model incorporates various physiological parameters and integrates data from multiple sources to simulate Propofol dynamics over time (up to 10 hours post-induction). Our findings underscore the importance of accurate modeling in anesthetic pharmacokinetics, providing insights applicable in both clinical settings and research.
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Integrative PBPK Model for Blood Propofol Concentration Over Time After Induction
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Presentation Transcript
7 6 5 4 PBPK model Blood propofol concentration (mg/ml) 3 2 Integrative model 1 0 8 0 2 4 6 10 Time after induction (h)
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