1 / 18

Interpenetrating Networks for Delivery Systems

Interpenetrating Networks for Delivery Systems. Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass. Overview. Background Information

vian
Télécharger la présentation

Interpenetrating Networks for Delivery Systems

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Interpenetrating Networks for Delivery Systems Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass

  2. Overview • Background Information • Interpenetrating Networks (IPNs) • Competing Products • Past Semester • Problem Statement • Design Requirements • Proposed Designs • Future Work • Questions

  3. Problem Statement • To design a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).

  4. *Kao, W.J. Conventional Dressings IPN Irregular Wound Background: IPNs • What is an IPN? • A bioactive wound dressingfor • large surface area wounds

  5. Kao, W.J. Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands Biodegradable Gelatin Backbone PEG-diacrylate (2-3.4 kDa ) Soluble Therapeutic(s) in situ UV curing Background: IPNs IPNs are composed of multiple components Solution (drugs + matrix component)

  6. Clinical Application • Benefits • Biocompatible • Moist healing environment • Conforms to irregular wounds • Covers large surface area wounds • Delivers drug cocktails • Issues • Heat • Uneven administration • Lengthy application process

  7. Day 7 Day 3 Day 1 Current Administration Technique 1 Mix Ingredients/ drug(s) in single container 2 Heat • Components • pegDA • Gelatin • Photoinitator • Water Inject Syringe is use to administer solution 3 4 Cure in 30 sec to obtain a rubbery film 7 Clean 6 Sustained Release while the IPN biodegrades 5 Cover *Kao, W.J

  8. Last Semester • Focused on optimizing IPN solution composition • Gelatin dissolution impacts efficacy & administration of IPNs • Integrated laboratory & design-based research • Developed IPN recipe • Modified IPN administration This Semester • Administration technique • Product packaging • Further laboratory research

  9. Design Requirements • Minimal preparation and effort required to administer the IPN • Compartmentalization • Even spray pattern • Uniform solution • Straightforward mixing procedure • Disposable • Can be sterilized • Low-cost • Few parts

  10. Competing Products • Duoject Medical Systems Inc. • Inter-Vial • Debiotech • Clip’n’ject • U-Mix • Travel Bottle • Hansplast • Spray Bandage

  11. Design 1: Syringe • Liquid in plunger • Powder stored in barrel • Mechanism to release liquid into powder • Hand mixing • Hand powered delivery • Luer-Lock spray tip

  12. Design 1: Syringe • Pros • All in one packaging • Easy application • Controllable spray rate • Cons • Custom manufacturing required • Moving parts

  13. Design 2: Pressurized Bottle • Manual pressure vacuum • Unique cap design • Facilitates stirring mechanism • Perforated seal

  14. Design 2: Pressurized Bottle • Pros • Parts readily available • Few modifications necessary • Spray is sustained for approx. 20 sec • Cons • Pressure building is laborious • All parts must be packaged separately • Pressure feature comes at a cost ($14) • Only one size is available

  15. Design 3: Spray Bottle • Threaded straw • Blades puncture inner container • Single pump, single spray • Includes mixing mechanism

  16. Design 3: Spray Bottle • Pros • Incorporates mixing mechanism • Provides slow release of photo-initiator • Cons • Laborious application technique • Non-standard parts

  17. Design Matrix

  18. Future Work • Test cold-water soluble gelatin • Develop-Manufacture-Test prototype • Research photoinitiators • Continue patent search

More Related