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Interpenetrating Networks for Delivery Systems

Interpenetrating Networks for Delivery Systems. Client: Professor John W. Kao Advisor: Professor Kristyn Masters Claire Flanagan Ashley Huth Max Michalski Adam Rieves. Overview. Problem Statement Background Information Design Constraints Design Approaches Preliminary Data Conclusions.

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Interpenetrating Networks for Delivery Systems

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  1. Interpenetrating Networks for Delivery Systems Client: Professor John W. Kao Advisor: Professor Kristyn Masters Claire Flanagan Ashley Huth Max Michalski Adam Rieves

  2. Overview • Problem Statement • Background Information • Design Constraints • Design Approaches • Preliminary Data • Conclusions

  3. Problem Statement • Our goal is to create a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).

  4. InterpenetratingNetwork (IPN) Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands BiodegradableGelatin Backbone Bifunctional PEG Linkers PEG-diacrylate (2-3.4 kDa ) Soluble Therapeutic(s) in situ UV curing Solution (drugs + matrix component) *Kao, W.J

  5. Conventional Dressings IPN Irregular Wound Clinical Applications • Benefits • Moist healing environment • Conforms to irregular wounds • Covers large surface areas • Delivers drug cocktails • Very biocompatible • Issues • Uneven administration • Reconstitution Method • Heat • Time • Shelf life *Kao, W.J.

  6. Ideal ClinicalAdministration Mix 1 ingredients w/ drug(s) in one container 2 Shake 3 Spray with a controlled distribution over irregular wound surface 4 Cure in 30 sec to obtain a rubbery film 7 Clean 6 Sustained Release while the IPN biodegrades 5 Cover Day 7 Day 1 Day 3 *Kao, W.J

  7. Design Constraints • Clinically applicable • No special equipment required • Simple reconstitution methods • Administration via spray bottle • Completely reconstitutes • Meets viscosity requirements • Cure time < 60 seconds • Improves Shelf Life

  8. Exothermic Reaction Resistive Element Pros Feasibility Viscosity Passive Procedure Cons Cost Client Preference Safety Approach 1: Heating Element

  9. Alter pH Add Surfactants Try Buffer Varieties Pros Client Preference Reconstitution Time Cost Cons Feasibility Safety Active Procedure Approach 2: Research

  10. Design Matrix

  11. Preliminary Data **Water at 60 ºC

  12. Preliminary Data **All solutions at room temperature **Final solution 10% gelatin

  13. Conclusions • We hope to further the clinical applications of IPNs • Future Work • Continue literature research • Gather data • Test complete IPNs • Reconsider design approach

  14. Questions ?

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