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Evidence Based Medicine:

Evidence Based Medicine:. An Introduction. What is Evidence Based Medicine?. …an approach to practicing medicine in which the clinician is aware of the evidence in support of clinical practice, and the strength of that evidence.

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Evidence Based Medicine:

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  1. Evidence Based Medicine: An Introduction

  2. What is Evidence Based Medicine? • …an approach to practicing medicine in which the clinician is aware of the evidence in support of clinical practice, and the strength of that evidence. • Combines your clinical knowledge with your knowledge of your patient, with evidence from the literature

  3. Why use EBM? • Improves patient care. • Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia, J. Pediatrics 140(5):565-9, 2002 May. • It helps to avoid legal pitfalls. • Lawyer sued for missing a transected pancreas in injured child. • Medical school knowledge quickly becomes dated and/or forgotten • Children to get Viagra in lung disease trial, NewScientist.com, July 23, 2002.

  4. EBM is a life long learning process that includes: • Converting clinical questions into a searchable format. • Efficient searching skills. • Critically assessing the information for validity and usefulness.

  5. EBM is a lifelong learning process that includes: • Evaluating the performance of the information in clinical practice. • Discovering areas where more research is needed. • Applying the information in clinical practice with physicians.

  6. The First Step of EBM • Convert a clinical situation into a searchable, (and hopefully answerable) question using • PICO • PATIENT • INTERVENTION • COMPARISON • OUTCOME

  7. PICO P “Patient” refers to the person presenting with the problem, or more simply, to the problem itself. Both concepts are important in searching. atient or Problem I ntervention C omparison O utcome

  8. PICO P “Intervention” refers to the action taken in response to the problem. This is often a drug or surgical procedure, but it can take many forms atient or Problem I ntervention C omparison O utcome

  9. PICO P atient or Problem “Comparison” refers to the benchmark against which the intervention is measured. Often it refers to another treatment, no treatment, or a placebo. I ntervention C omparison O utcome

  10. PICO P atient or Problem I ntervention “Outcome” refers to the anticipated result of the intervention. C omparison O utcome

  11. Clinical Scenario You are seeing a child with acute diarrhea and a lower respiratory infection. You know that zinc supplementation will improve the diarrhea, but will it help the respiratory infection as well? Or is there something else that you can add that might work with the zinc? P I C O Child with diarrhea and respiratory infection Zinc supplementation Zinc supplementation plus something else Improvement in diarrhea and respiratory infection

  12. Wedge of Evidence • Opinion papers, editorials • Case studies, case reports • Laboratory Testing • Animal Experiments • Early Human Experiments-Phase I Trials • Case Series-Phase II Trials • Clinical Trials-Phase III Trials

  13. Reviews • Systematic v. Narrative Reviews • Systematic Review: • CLEAR CLINICAL QUESTION • CONCLUSION BASED ON DATA • Narrative Review: • NO CLEAR QUESTION • NO EVIDENCE CITED

  14. Searching Tools • Medline • Both PubMed and Ovid are often refered to as Medline. They contain the same information. • PubMed Clinical Queries • Ovid • Cochrane’s Database • Best Evidence

  15. PROS OVID PubMed • Related articles • Clinical Queries • Book links • Links to other NCBI databases • Clipboard • Free! • EBM Reviews limit • More limits • Links to fulltext • Can e-mail results • Search multiple databases • Links to catalog Same Medline, different interface

  16. CONS PubMed OVID • Can’t e-mail results easily • Automatically explodes search • MESH browser does not map as well as the main search page • Interface not as intuitive • Keyword search not so good • To many steps to do a complicated search • Sophisticated searcher may be frustrated • Very expensive

  17. Clinical Queries in PubMed Applies research methodology filters • Categories: • Therapy • Double-blind randomized controlled trials • Diagnosis • Compares new test to the gold standard; controlled trials • Etiology • Longitudinal Studies • Prognosis • Cohort studies or survival analyses

  18. PubMed's Clinical Queries • Emphasis • Different than the diagnostic meaning of the words • Sensitivity • Broad-based • Specificity • Targeted, Narrower

  19. OVID • Cochrane Collection • Systematic Reviews; Database of Reviews of Systematic Reviews; Cochcrane Controlled Trials Register • Best Evidence • Electronic version of ACP Journal Club • Most information contained in commentary

  20. Cochrane Database of Systematic Reviews • The Cochrane Database of Systematic Reviews (COCH) includes the full text of the regularly updated systematic reviews prepared by The Cochrane Collaboration. • The reviews are presented in two types: • Complete reviews - Regularly updated Cochrane Reviews, prepared and maintained by Collaborative Review Groups • Protocols - Protocols for reviews currently being prepared. Protocols are the background, objectives and methods of reviews in preparation.

  21. DARE • The Database of Abstracts of Reviews of Effectiveness (DARE) includes the Cochrane Database of Systematic Reviews and ACP Journal Club • DARE is a Full Text database containing critical assessments of systematic reviews from a variety of medical journals. DARE consists of structured abstracts of systematic reviews from all over the world. DARE records cover topics such as diagnosis, prevention, rehabilitation, screening, and treatment.

  22. ACP Journal Club • The ACP Journal Club Collection consists of two journals ACP Journal Club, a publication of the American College of Physicians, and Evidence-Based Medicine, a joint publication with the British Medical Journal Group. • The editors of ACP Journal Club screen the top clinical journals on a regular basis and identify studies that are both methodologically sound and clinically relevant. They write an enhanced abstract of the chosen articles and provide a commentary on the value of the article for clinical practice. Using this source, clinicians can quickly understand and apply to their practice important changes in medical knowledge, without having to read and synthesize for themselves thousands of journal articles.

  23. CCTR • CCTR is a bibliographic database of definitive controlled trials. These controlled trials have been identified by the distinguished contributors to the Cochrane Collaboration. They search the world's health care journals systematically, have combined results to create an unbiased source of data for systematic reviews. • CCTR contains over 300,000 bibliographic references to controlled trials in health care. Contributors to the Cochrane Collaboration follow quality control standards to ensure that only reports of definite randomized controlled trials or controlled clinical trials are included. • Although many reports of trials are included in MEDLINE, others are not easily identified as randomized controlled trials; and as such, researchers may overlook them in the search for relevant studies for systematic reviews.

  24. Medline vs Reviews • Clinical focus • Keyword searching is better • Smaller • Information gaps-topics not as well covered • Goes back further • Bigger • Sometimes too many citations

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