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NUTRITION & PARKINSON’S DISEASE

NUTRITION & PARKINSON’S DISEASE. Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine. NOT A DIET!. Not a trend, fad, or other temporary alteration GOALS: Become Informed Understand consequences of your actions

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NUTRITION & PARKINSON’S DISEASE

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  1. NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine

  2. NOT A DIET! Not a trend, fad, or other temporary alteration GOALS: • Become Informed • Understand consequences of your actions • Make wiser decisions tomorrow than you made yesterday

  3. WHAT IS NUTRITION? Latin: to nourish We think of ourselves as self-contained separate from our environment Me I Environment

  4. “NO MAN IS AN ISLAND, ENTIRE OF ITSELF;” JOHN DONNE, ENGLISH POET Nutrition is the study of the inter-dependence between health and the environment.

  5. NUTRIENTS • Are the things provided by the environment, that encourage, support, and sustain function. • i.e. gas, oil in a car. Environment: Sunlight provides vitamin D Gut bugs provide immunomodulation Food provides vitamins, minerals

  6. NUTRIENTS • Macro: • Fat, Protein, Carbohydrate, (Alcohol) • Micro: • Vitamins • B-vits, Vit C, Vit A, Vit D, etc. • Minerals • Ca, Mg, K, I, Li, Na, Mn, …. (not all minerals are nutrients) • Accessory: • Co-Q10, carnitine, cholesterol, …

  7. Prospective, Observational Studies (don’t tell about treating disease) THAT WHICH PREVENTS…

  8. PROTECTIVE AGAINST PD (THE PRUDENT DIET) • High intakes of: • Fruit • Vegetables • Legumes (beans) • Whole grains (rice, quinoa) • Nuts • Fish • Poultry • Low intake of: • Saturated fat (cream, red meat, pork) • Moderate intake of: • Alcohol Am J Clin Nutr 2007;86:1486-1494

  9. WHAT FOODS WEREN’T PROTECTIVE? PRUDENT DIET WESTERN DIET High intakes of: Red meat Processed meat Refined grains French fries Desserts & sweets High fat dairy products • High intakes of: • Fruit, Vegetables • Legumes/ Nuts • Whole grains • Fish • Poultry • Moderate alcohol • Limited saturated fat

  10. DAIRY • Nurses’ Health Study (121000) & Health Professional Follow-up Study (51000) • 1.8x risk • Honolulu Heart Program (7500 men) • 2.3x risk • American Cancer Society’s Cancer Prevention Study II Nutrition Cohort (57000 men, 73000 women) • Up to 1.8x risk

  11. WHAT CONSTITUTES DAIRY? Individuals who consume 3-6 servings of dairy per day have 60-80% greater risk of developing PD than those who rarely or never consume it. Milk, butter, cheese, cream, half & half, ice cream, sour cream, cottage cheese, cream cheese, yogurt, frozen yogurt, whey protein

  12. RETROSPECTIVE STUDIES

  13. TEA (GREEN & BLACK) Consumption of 3+ cups/ day of tea delayed motor symptom onset by 7.7 years. Kandinov B, et al. Parkinsonism Relat Disord 2009;15(1):41-6

  14. But what if I already have the disease.? INTERVENTION STUDIES

  15. IF YOUR BELLY IS BIGGER THAN YOUR HIPS…THIS ONE’S FOR YOU. Calorie Restriction American’s tend to: Eat too much Eat for reasons other than to nourish CR is typically defined as 10-25% fewer calories than the average Western diet.

  16. CR CLINICAL TRIALS Rhesus monkeys (Maswood N, et al) Natl Inst Aging • 30% CR x 6 mo prior to MPTP • Controls • Both groups showed symptoms after MPTP • At 6 months: Significantly fewer symptoms in the CR group Significantly increased concentrations of GDNF Increased survival of DA neurons (not stat sig) Proc Natl Acad Sci USA 2004;101:18171-76

  17. GOAL- CONCENTRATE NUTRIENTS • Macro == calories • Fat, Protein, Carbohydrate, (Alcohol) • Micro: • Vitamins • B-vits, Vit C, Vit A, Vit D, etc. • Minerals: • Ca, Mg, K, I, Li, Na, Mn, etc. • Accessory: • Co-Q10, carnitine, cholesterol, etc.

  18. NUTRIENT DENSE FOODS: • Nutrient- Dense Foods (usually bright colors) • Kale, spinach, chard • Carrots, beets, • Tomatoes • Broccoli • Berries, cherries • Salmon, sardines, herring • Eggs • NOT nutrient-dense • Donuts • Potato chips • French fries • Bread • Pasta • Soda • Candy, sweets • Fast food • Ice cream

  19. INCREASE DIETARY ANTIOXIDANTS (ORAC) • Pinto beans 11864 • Red kidney 13259 • Small red 13727 • Blueberry 10000 • Cranberry 8983 • Artichoke hearts 7900 • Walnuts 3846 • Hazelnuts 2739 • Whole grain bread 398 • Popcorn 157 • Ketchup 6

  20. DHA (FISH OIL) Ann Neurol 2006;59:282–288 Anti-inflammatory, in general Reduces dyskinesias

  21. A FEW WORDS ABOUT SUPPLEMENTS: • Purity • Potency • Access • Cost (vs. Prescriptions) • Insurance coverage • Benefit vs. Risk

  22. THANKS! • WA APDA • Kadlec Neurological Resource Center • Teva

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