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Biomarkers and Drug Discovery

Biomarkers and Drug Discovery. Angie Pannier Mathias Schubert Pat Dussault Surinder Batra. Charge:. Your task is to develop core ideas/projects for an $8-10M ($1.25-1.5M per year for 5 years) NIH Center proposal. Specifically, you should consider the following questions.

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Biomarkers and Drug Discovery

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  1. Biomarkers and Drug Discovery • Angie Pannier • Mathias Schubert • Pat Dussault • Surinder Batra

  2. Charge: • Your task is to develop core ideas/projects for an $8-10M ($1.25-1.5M per year for 5 years) NIH Center proposal. • Specifically, you should consider the following questions

  3. Briefly describe the core projects your group would design for the Center. Please dream big. • Cancer diagnostics • Noninvasive • Imaging-based (small molecules) • Blood-borne (cellular or molecular targets) • Detection with nanoparticles and then novel characterization techniques (to determine presence of ligand) • Nanohybrid materials--Biomolecule capturing/filtering/microfluidics/readout techniques • Detection for proteins, miRNAs, small molecules • Diagnostics/Disease Screening Center (broader than cancer)—” Nanohybrid Biomaterials for Diagnostics” • Screen for miRNAs • Sensitive RNA detection methods and probes • Sequencing • Profiles • Bioinformatics • Personalized Medicine • Combine above with additional therapies

  4. Identify the key faculty from both campuses to involve in these projects. Include their strengths. (UNMC on next slide) • UNL FacultyStrengths • Pat Dussualt • David Hage • Mathias Schubert • Angie Pannier • Eva Bachman-Schubert • Ravi Saraf • Yongfeng Lu • Rebecca Lai • Hendrik Viljoen • Yuris Dzenis • Ming Han • Srivatsan Kidambi • Dennis Alexander • Greg Bashford • Shadi Othman • Jung Yul Lim

  5. Identify the key faculty from both campuses to involve in these projects. Include their strengths. • UNMC Faculty Strengths • Surinder Batra • Tony Hollingsworth • Aaron Sasson • Michelle Ouetllet • John Davis • Steve Remenga • Subodh Lele • Hamid Band • Vimla Band • Kay Wagner • Ken Cowan • CDDN (Sasha Kabanov and Tatiana Bronich) • Sanjay Singh • Howard Gendelman • Ken Bayles

  6. Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects. • Better communication between campuses (and PIs) • Expand nanofabrication facilities (microelectronics, prototyping) • Microfluidics faculty member • New graduate program

  7. List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested. • J.A. Woollam Co. • LICOR • P & G • Abbott • PanCan • American Cancer Society • All disease specific….

  8. Describe how you would link the Center to other campus resources. • Links to CDDN, NCMN, MR-SEC, Center for Biotechnology, Nebraska Gateway for Nutrigenomics, UNMC Bioinformatics, Center for Neurosciences, Genetics Center

  9. Increase communication between campuses (intracampus) • “Stanford BioDesign” analogy • Poster Sessions • Research talks • Biologists/clinicians: What are the problems? • Engineers: What are the tools?

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