Stepholidine: A Promising Antipsychotic from Chinese Herb

Jan 17, 2026

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Stepholidine, a compound isolated from a traditional Chinese herb, shows potential as an antipsychotic agent. It operates as a D1 dopamine receptor agonist while antagonizing the D2 dopamine receptor, indicating a unique mechanism of action that may offer therapeutic benefits in mental health treatments. The enantioselective total synthesis of (-)-(S)-Stepholidine was detailed by Cheng and Yang in the Journal of Organic Chemistry. This compound's synthesis and its implications for psychiatric disorders highlight its importance in medicinal chemistry.

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Stepholidine: A Promising Antipsychotic from Chinese Herb

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Stepholidine is a promising anti-psychotic. This molecule was isolated from a Chinese herb. It is a D1 dopamine receptor agonist, but a D2 dopamine receptor antagonist. Cheng, Jian-Jun; Yang, Yu-She. Enantioselective Total Synthesis of (-)-(S)-Stepholidine. Journal of Organic Chemistry (2009), 74(23), 9225-9228.

Bishler-Napieralski Reaction The Bishler-Napieralski Reaction is an electrophilic aromatic substitution whereby a suitably placed amide is transformed into an electrophile through the action of phosphorus oxychloride.