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This research investigates the intricate relationships between carbohydrates and gut microbiota, focusing on characterizing microbial networks responsible for fiber fermentation. Key aims include tracking fermentation locations and products, identifying carbohydrates that stimulate beneficial populations like butyrate producers, and understanding individual differences in microbial responses. To achieve this, high-throughput functional microbiomics, stable isotope-based techniques, and in vitro screenings will be employed, providing insights into the genetic potential and functionality of our gut microorganisms.
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Novel Technologies to assess Gut Health Claims for Carbohydrates Subthema: MicrobiotaNaam trekker: Hauke SmidtAffiliatie: Wageningen UniversiteitContactgegevens: hauke.smidt@wur.nl
Key aims • Characterize microbial networks responsible for fibre fermentation • Track place & products of fermentation • Identify carbohydrates that stimulate specific populations and products (e.g. butyrate producers) • Effect of carbohydrates on microbial determinants of functionality (e.g. surface decoration) • Personalized ingredients - Differences between individuals/enterotypes?
Key technologies needed • HTP functional microbiomics approaches for whole microbiota & key populations • Stable isotope-based identification of fermentative microbial networks • HTP in vitro screening capacity • Carbohydrate metabolite profiling in intestinal samples
Which microbes are there? What are the microbes doing? What is the genetic potential?
