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Complement and Mediators of Inflammation

Complement and Mediators of Inflammation. Lecture C4-06M Thursday, November 7, 2002 S TEPHEN R. J ENNINGS , P H .D. Redness. Heat. Pain. Swelling. Overview Of Inflammation. Classic Signs: Swelling, Redness, Heat, Pain, Altered Function. The Complement (C’) System.

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Complement and Mediators of Inflammation

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  1. Complement and Mediators of Inflammation Lecture C4-06M Thursday, November 7, 2002 STEPHEN R. JENNINGS, PH.D.

  2. Redness Heat Pain Swelling Overview Of Inflammation Classic Signs: Swelling, Redness, Heat, Pain, Altered Function

  3. The Complement (C’) System The Complement system consists of a complex series of fifteen proteins, many of which are proteineases. It is a primitive form of defense against infection, being conserved throughout evolution. It performs three vital functions: cell activation cytolysis opsonization. Is one of the first systems activated in the response to infection. The Complement system can be considered as a cascade of interacting proteins, acting in a defined manner, resulting in the initiation of important innate biological effects.

  4. Pathways of Complement Activation

  5. Pathways of Complement Activation

  6. The Classical Pathway C1qrs Complex

  7. The Classical Pathway C1qrs binds Fc region of IgG

  8. The Classical Pathway Formation of the Classical C3 Convertase

  9. The Classical Pathway Formation of the Classical C3 Convertase

  10. The Alternative Pathway Formation of Alternative C3 Convertase

  11. The Alternative Pathway Formation of Alternative C3 Convertase

  12. Formation of the C5 Convertases

  13. Formation of the Membrane Attack Complex (MAC)

  14. Terminal Complement Components

  15. Biological Functions of Complement

  16. Complement Components and Inflammation

  17. Overview of Complement-mediated Biological Effects

  18. Regulation of Complement Activation

  19. Regulation of Complement Activation

  20. Mediators of Inflammation Function Mediators Increased vascular permeability Histamine, bradykinin, C3a, C5a, PGE2, prostacyclins, Hageman factor. Vasoconstriction Thromboxane A2, leukotrienes C and D, C5a, LTB4, formyl peptides Smooth muscle contraction C3a, C5a, histamine, LTB4, leukotrienes C and D, thromboxane A2, bradykinin Increased endothelial cell stickiness IL-1, TNF-a, endotoxin, LTB4 Pyrogens (Fever induction) IL-1, TNF-a, PGE2 Pain PGE2

  21. Lipid Mediators of Inflammation Metabolites of Membrane Phospholipids

  22. The Coagulation Pathway

  23. Cytokines in Inflammation

  24. Actions of TNF-a

  25. Proinflammatory Cytokines

  26. Function of IL-8 (Chemokine)

  27. Signaling through Chemokine Receptors

  28. Leukocyte Adhesion and Extravasation

  29. Overview Of Inflammation

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