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Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS)

Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS). Julian Trollor, Evelyn Smith. The Model. The People. MAS & OATS Investigators, Staff & participants Evelyn Smith (post-doctoral) Key collaborators Lesley Campbell & Katherine Samaras ( Garvan ) Bernhard Baune (JCU)

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Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS)

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  1. Metabolic/Inflammatory/CVS & NutritionAdd-ons to MAS (and OATS) Julian Trollor, Evelyn Smith

  2. The Model

  3. The People • MAS & OATS Investigators, Staff & participants • Evelyn Smith (post-doctoral) • Key collaborators • Lesley Campbell & Katherine Samaras (Garvan) • Bernhard Baune (JCU) • Stephen Lord, Jackie Close, Alfred Wong (NeurA) • Jayashree Arcot (UNSW Nutrition) & Sharon Ong (PhD Scholar) • Sam Breit & David Brown (St Vincents Centre for Applied Medical Research) • Diane Fatkin (Victor Chang) • Paul Mitchell and Jie Jin Wang (Westmead)

  4. MAS • Bloods from Wave 1 & 2 (most participants) • Inflammatory markers • insulins • Lab assessments wave 2 (half of the participants) • anthropometric measures • CVS: Arterial stiffness, ECG, tilt BP • Retinal photography • Lab assessments wave 3 (aiming for half of the participants) • anthropometric measures • CVS: Arterial stiffness, ECG

  5. Outputs: MAS Wave 1Planned or In Progress

  6. Outputs: MAS Wave 1Potential

  7. Outputs: MAS Wave 2Potential

  8. Systemic Inflammation and Cognition in the Elderly. Neuropsychiatric Disorders. Miyoshi K (ed) Springer • Systemic inflammation is associated with MCI and its subtypes – the Sydney Memory and Aging Study • Our findings suggest an association between specific inflammatory markers and MCI subtypes, highlighting sex differences in the association with MCI • Accepted Dementia and other Cognitive disorders • The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study • markers of systemic inflammation are related to cognitive deficits in a non-clinical community-dwelling elderly population, independent of depression, cardiovascular or metabolic risk factors, or presence of apolipoprotein ε4 genotype. • Submitting to Age

  9. The relationship between adiposity and cognition, MCI and its subtypes – the Sydney Memory and Ageing Study • In progress: underweight is associated with lower cognition, whereas obesity is associated with high cognitive scores • The association of diabetes, impaired fasting glucose and insulin resistance with cognition, MCI and its subtypes: the Sydney Memory and Ageing study • In progress: Diabetes is associated with lower cognition. IFG is not. Insulin resistance is common in AD, is it more common in amnestic MCI? Yes

  10. Depression, inflammation and cognition • Inflammation is associated with impaired mood • Inflammation negatively impacts on general functioning in the elderly • Inflammation mediates the relationship between mood and cognitive performance

  11. Opportunities • 2 ILPs for 2011 • Inflammation and Cognition PhD • Lots of data, open to group use

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