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CIRRHOSIS Pathophysiology & Complications

CIRRHOSIS Pathophysiology & Complications. What is Cirrhosis?. Cirrhosis. Definition: Hepatic necrosis and degeneration combined with hepatic regeneration and fibrosis leading to Nodular formation. Normal liver functions Carbohydrate Metabolism Hypo- or hyperglycemia

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CIRRHOSIS Pathophysiology & Complications

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  1. CIRRHOSIS Pathophysiology & Complications

  2. What is Cirrhosis?

  3. Cirrhosis Definition: Hepatic necrosis and degeneration combined with hepatic regeneration and fibrosis leading to Nodular formation

  4. Normal liver functions • Carbohydrate Metabolism • Hypo- or hyperglycemia • Fatty Acids Metabolism • Lipid Transport • Hyper- or hypolipidemia • Proteins Metabolism • Serum Albumin • Vitamin K–Dependent Blood Coagulation Proteins • Bilirubin Metabolism • Bile Production • Fat-Soluble Vitamins • Detoxification • Drugs and hormones • Providing continual source of energy for entire body • Regulation of storage and modulate availability of systemic nutrients • Subject to hormonal modulation by endocrine organs • (Pancreas, adrenal gland, and thyroid, neuronal regulation)

  5. 1. Atrterial System 3. Venous System 2. Capillary System

  6. 5. Venous System 4. Second Visceral Capillary System 1. Atrterial System 2. First Visceral Capillary System 3. Venous System 3. Visceral Venous System 2. Capillary System

  7. Normal Liver Histology CV 2-3 mmHg 6 mmHg PV

  8. Portal Fibrosis = 1 None = 0 Bridging Fibrosis = 3 Cirrhosis = 4

  9. What is patophysiology of Cirrhosis?

  10. Cirrhosis Causes (Etiology of chronic necrosis) + Host (Liver reaction) Lead to Cirrhosis & complications

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