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Clinically significant improvements in function

Clinically significant improvements in function. Kathleen M Carrroll PhD, Yale University Supported by NIDA DA039136 NIDA P50 DA009241 NIDA U10 DA015831 NIDA DA041661 MTP Research Group. Clinically significant outcomes. ‘Safe’ levels of use Short versus long term consequences

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Clinically significant improvements in function

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  1. Clinically significant improvements in function Kathleen M Carrroll PhD, Yale University Supported by • NIDA DA039136NIDA P50 DA009241 • NIDA U10 DA015831 • NIDA DA041661 MTP Research Group

  2. Clinically significant outcomes • ‘Safe’ levels of use • Short versus long term consequences • Defining ‘success’, responder • Feel and function • Cannabis dependence symptoms • Cannabis-related problems • Craving and withdrawal symptoms, sleep quality • ASI days of problems (floor effects for composites?) • Quality of life (Brezing et al, 2018)

  3. MTP (JCCP, 2004): N=450 outpatient cannabis dependent individuals, 3 sites

  4. MTP: Change in DSM-IV Dependence symptoms by treatment

  5. DSM-IV Abuse Symptoms by time

  6. Abstinent versus improved (no DSM dependence symptoms) versus not improved, past 90 days

  7. Marijuana Problems Scale-MTP

  8. Young probation referred marijuana users, N=136 • Average age 21 (range 18-25) • 90% male • 60% African American, 13% Latin American • 50% did not complete high school • 51% unemployed • Average 5 previous arrests • Average total months incarceration=9

  9. Treatment conditions

  10. Retention: Percent completing treatment Carroll et al, JCCP, 2006

  11. “CM response” outcome: Completing treatment and submission of 1 or more marijuana free urine specimens Carroll et al, JCCP, 2006

  12. Point-prevalence (marijuana-free urines specimens at 6 month follow-up) Carroll et al, JCCP, 2006

  13. Marijuana Problem Scale by group

  14. Cannabis tx datasets, N=264 (90% fup) • Potential outcomes • “Problem free functioning” • Change in DSM symptoms count • Reduction in cannabis-related consequences, problems • Quality of life

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