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Understanding Biomarkers: A Comprehensive Overview and Their Role in Atherosclerotic CVD

This article explores key concepts related to biomarkers in the context of atherosclerotic cardiovascular disease (CVD). It outlines desirable features of biomarkers, measures of test performance, sources of variability, and available development techniques. Additionally, it discusses approaches for defining abnormal values and provides a glossary of terms relevant to the field. The article also highlights the five phases of biomarker development and poses critical questions for practical application. Overall, it serves as an essential guide for understanding the significance and application of biomarkers in clinical practice.

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Understanding Biomarkers: A Comprehensive Overview and Their Role in Atherosclerotic CVD

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  1. Biomarkers: A Basic Glossary Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  2. Desirable Features of Biomarkers of Atherosclerotic CVD R. S. Vasan. Circulation 2006;113:2335-2362

  3. Measures of biomarker test performance Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  4. Approaches to defining “abnormal” biomarker values FN indicates false-negative; FP, false-positive; TN, true-negative; TP, true-positive; Pts, patients; and F/U, follow-up Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  5. Sources of Biomarker Variability R. S. Vasan. Circulation 2006;113:2335-2362

  6. Techniques Available for Biomarker Development Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  7. Brief “Omics” Glossary R. S. Vasan. Circulation 2006;113:2335-2362

  8. Glossary of Terms for Select Techniques Used in the OMICs Toolbox R. S. Vasan. Circulation 2006;113:2335-2362

  9. Five phases of biomarker development: from discovery to delivery Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  10. Some Key Questions to Ask Before Using a New Biomarker in Practice Ramachandran S. Vasan. Circulation 2006;113:2335-2362

  11. Biomarkers for Identifying the Vulnerable Patient R. S. Vasan. Circulation 2006;113:2335-2362

  12. Biomarkers of acute coronary syndromes Ramachandran S. Vasan. Circulation 2006;113:2335-2362

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