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Tomris Cesuroglu, MD Institute for Public Health Genomics

PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011. Tomris Cesuroglu, MD Institute for Public Health Genomics. Research into Child Health in Europe RICHE. http://childhealthresearch.eu. RICHE. An EU funded project (FP7, Mar 2010 to Feb 2013)

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Tomris Cesuroglu, MD Institute for Public Health Genomics

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  1. PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011 Tomris Cesuroglu, MDInstitute for Public Health Genomics

  2. Research into Child Health in EuropeRICHE http://childhealthresearch.eu

  3. RICHE An EU funded project (FP7, Mar 2010 to Feb 2013) A project for child health researchers, practitioners, policy makers, and those who make decisions affecting children Defining the current pattern of child health research in Europe, seeing what's not being done, and identifying paths to the future of the research Future proofing child health research policy in Europe Meeting the future needs of European policy makers, funders, and children.

  4. Home Page

  5. An example

  6. What's to be done? Join us! Put up your own work Put up your colleagues Put up your projects Put up your report Put up your funders

  7. Perspectives in Personalized Health CareTomris Cesuroglu, MDInstitute for Public Health Genomics PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011

  8. 77% of burden of disease 1% of burden of disease 22% of burden of disease Disease threshold _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Life style External factors Genetic structure Genetic diseases Complex diseases External factors *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

  9. Start Codon Stop Codon ┐└ ┐└ TAT TCG TAC GGC TAC ATA CGT ACC GTA AAT TCG ATT CGA TGA ATA AGCATG CCG ATG TAT GCA TGG CAT TTA AGC TAA GCT ACT An Example to a Single Nucleotide Polymorphism (SNP)

  10. Start Codon Stop Codon ┐└ ┐└ TAT TCG TAC GGC TAC ATA CGT GCC GTA AAT TCG ATT CGA TGA ATA AGCATG CCG ATG TAT GCA CGG CAT TTA AGC TAA GCT ACT An Example to a Single Nucleotide Polymorphism (SNP)

  11. Gene and Environment/Life Style Interaction Genetic Polymorphism Dark skin Fair skin Which one is better? *Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research

  12. Genetic variation: Is it good or bad?

  13. Genetic variation: Is it good or bad?

  14. Genetic variation: Is it good or bad?

  15. Genetic variation: Is it good or bad?

  16. Genetic variation: Is it good or bad?

  17. Genetic variation: Is it good or bad?

  18. Assamoa Eric Transcription (mRNA production) Transcription (mRNA production) Translation in ribosom (synthesis of amino acid chain) Translation in ribosom (synthesis of amino acid chain) GSTP 1 (A313G Homozygous) GSTP 1 Protein Protein Effective detoxification Ineffective detoxification

  19. Disease Threshold Early Symptoms Threshold Check-Up Early Diagnosis Diagnosis and Treatment Life Style and Environmental Conditions Genetic Predisposition Death Conception Early Symp. Phase II Pathology Development Phase I Disease Phase III *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

  20. Thankyouforyourattention! Tomris Cesuroglu, MD t.cesuroglu@maastrichtuniversity.nl

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