SlideServe
Télécharger Obtenir Pro
Menu
Accueil Pro
Préférences
ApparenceLight Aide et commentaires
© SlideServe · v2026

Exercise 5

zandra avatar
zandra
8 diapositives · 254 Views · Oct 22, 2014

Exercise 5. Rem-610 March 3, 2010. Question 1. Use the IRIS Data base of the US‐EPA (http://www.epa.gov/iris) to find the Oral Reference Dose for cadmium consumed in food. Briefly, explain how the oral reference dose was developed. Oral RFD = 1E-3 mg/kg/day (EPA IRIS) or 1 ug /kg/day

Exercise 5 - slide 1
01 / 8Exercise 5
1 / 17

Télécharger la présentation

Exercise 5
Une image / un lien ci-dessous est fourni (tel quel) pour télécharger la présentation

Politique de téléchargement : le contenu du site vous est fourni TEL QUEL pour votre information et votre usage personnel ; il ne peut être vendu, concédé sous licence ni partagé sur d’autres sites sans l’accord de son auteur.Le contenu vous est fourni TEL QUEL, pour votre information et votre usage personnel uniquement. Téléchargez la présentation en cliquant sur ce lien. Lors du téléchargement, si vous ne parvenez pas à télécharger une présentation, l’éditeur a peut-être supprimé le fichier de son serveur.Pendant le téléchargement, si vous ne parvenez pas à obtenir une présentation, le fichier a peut-être été supprimé par l’éditeur.

F I N

Plus de contenu associé

Transcription de la présentation

  1. Exercise 5 Rem-610 March 3, 2010

  2. Question 1 • Use the IRIS Data base of the US‐EPA (http://www.epa.gov/iris) to find the Oral Reference Dose for cadmium consumed in food. Briefly, explain how the oral reference dose was developed. • Oral RFD = 1E-3 mg/kg/day (EPA IRIS) or 1 ug/kg/day • NOAEL = 1E-2 mg/kg/dayfrom “human studies involving chronic exposures” (US EPA 1984) • / 10x Uncertainty Factor

  3. Question 2 • Calculate the Hazard Index hazard associated with the consumption of 2 oysters per day by an adult of 70 kg. The average wet weight of an oyster is 45 g. Formulate a brief statement about the significance of your finding to an individual with this consumption behaviour. • 3-4 ug/g wet weight Cd in oysters (CFIA) • Average w.w. per oyster = 45 g • Consumption of 2 oysters/day = 270-360 ug/day • For 70kg individual, (270 to 360)/70 = 3.85 to 5.14 ug/kg/day • HI = exposure/RfD = 3.85/1 to 5.14/1

  4. Question 3a • Explore the relationship between the Hazard Index and the rate of oyster consumption per day.

  5. Question 3b • Recommend a human health advisory for the consumption of oysters for oyster consumers. • RfD = 1 ug/kg/day • For 70kg individual, 70 ug/day • 1x45 g oyster ~ 180 ug/day (assuming 4 ug/g ww) • (70 ug/day) / (180 ug/day/oyster) ≤ .399 oysters/day • =< 2.72 oysters/week

  6. Question 4 • Considering that the mean lifetime exposure to Cadmium in Canada from all foods (excluding shellfish) is 13.8 ug/person/day (Dabeka et al. 1987), would your answer to question 3 change? What would be your human health advisory for the consumption of oysters considering the background exposure of the Canadian population to cadmium. • (70 ug/day)/(180+13.8 ug/day) ≤ .36 oysters/day • ≤ 2.53 oysters/week

  7. Question 5 • Recommend a maximum acceptable limit for Cadmium concentrations in oysters aimed for the Canadian market. What are some of the difficulties associated with this approach. • (? ug/g-ww) * (2 oysters/day) * (45 g-ww/oyster) ≤ 70 ug/day – 13.8 ug/day (background) • (? ug/g-ww) ≤ .62 ug/g-ww

  8. Question 6 • Are oyster containing cadmium concentrations less than the limit you arrived at in question 5 safe to eat? Explain why?