1 / 27

Clinical experience with recombinant human FSH

This study focuses on the human follicle-stimulating hormone (FSH), comprised of two subunits: the alpha subunit with 92 amino acids and the beta subunit with 111 amino acids, each containing two carbohydrate moieties. The varying carbohydrate compositions lead to different isoforms of FSH, influencing its biological action and half-life. We also explore the expression of recombinant hFSH in CHO cells, highlighting the significance of glycosylation in hormone functionality and therapeutic applications.

zhen
Télécharger la présentation

Clinical experience with recombinant human FSH

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    3. Human FSH Glycoprotein hormone (a and b subunits). a subunit composed of 92 amino acids and carries 2 carbohydrate moieties. b subunit composed of 111 amino acids and carries 2 carbohydrate moieties. FSH molecule exists in many different (iso)forms: due to differences in carbohydrate moieties. Carbohydrate moieties are important in determining half-life of FSH and therefore modulates in-vivo biological action.

    10. Expression of hFSH in CHO Cells

More Related