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Mechanisms of AID Mediated Stabilization and Activation of Transcription in Cells

This study explores the multifaceted roles of Activation-Induced Cytidine Deaminase (AID) in transcriptional regulation, particularly focusing on its involvement in stabilizing single-stranded DNA (ssDNA) within transcription bubbles. We examine AID's interaction with key factors such as RNA polymerase II, UNG, and NHEJ processes that contribute to somatic hypermutation (SHM) and class switch recombination (CSR). The implications of these mechanisms on the creation of abasic sites and the potential role of other modifications are also discussed, shedding light on the complex landscape of gene activation.

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Mechanisms of AID Mediated Stabilization and Activation of Transcription in Cells

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  1. P AID 70 32 14 Supplementary figure 7 RGYW S REGION/ V GENE B CELL SPECIFIC ACTIVATION TRANSCRIPTION (other modifications?) AID P AID 70 STABILIZATION OF ssDNA IN TRANSCRIPTION BUBBLES 32 14 RNA pol II P DEAMINATION AID UNG 70 32 14 NHEJ REPLICATION APE1 SHM CSR CREATION OF ABASIC SITE (other mechanisms) (other mechanisms)

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