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Osteoscoop - Issue N°209 - November 2011

PTH deletion ameliorates the anomalies of FGF23-deficient mice by suppressing the elevated vitamin D and calcium levels . Osteoscoop - Issue N°209 - November 2011. FGF23. FGFR1c. Klotho. -. PTH secretion. +. Vitamin D (1,25(OH) 2 D) Ca 2+ serum level . -. 1. FGF23. FGR1c. Klotho.

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Osteoscoop - Issue N°209 - November 2011

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  1. PTH deletion ameliorates the anomalies of FGF23-deficient mice by suppressing the elevated vitamin D and calcium levels Osteoscoop - Issue N°209 - November 2011

  2. FGF23 FGFR1c Klotho - PTH secretion + Vitamin D (1,25(OH)2D) Ca2+ serum level -

  3. 1 FGF23 FGR1c Klotho - PTH secretion Low1 + Vitamin D (1,25(OH)2D) Ca2+ serum level High1 - Spleen Kidney 1- Fgf23-/- Soft tissue alteration Skeleton alteration Bad general health

  4. 2 FGF23 FGR1c Klotho - PTH2 secretion + Vitamin D (1,25(OH)2D) Ca2+ serum level Lower2 - Spleen Kidney 1- Fgf23-/- Soft tissue alteration Skeletal alteration Bad general health Larger and healthier mouse Partial amelioration of tissue atrophy Partial rescue of skeletal anomalities 2- PTH-/-Fgf23-/-

  5. 3 FGF23 FGR1c Klotho - +PTH3 PTH secretion + Vitamin D (1,25(OH)2D) Ca2+ serum level Higher3 - Spleen Kidney 1- Fgf23-/- Soft tissue alteration Skeletal alteration Bad general health Larger and healthier mouse Partial amelioration of tissue atrophy Partial rescue of skeletal anomalities 2- PTH-/-Fgf23-/- Decreased trabecular bone volume 30% mice died during experiment 3- Fgf23-/- + PTH

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