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Between-Arm Differences in HAM-A Improvement: Alprazolam vs. Comparators in Clinical Study

This forest plot illustrates the between-arm differences in the Hamilton Anxiety Rating Scale (HAM-A) improvement from baseline to final evaluation across various studies comparing Alprazolam to benzodiazepines such as Etizolam, Lorazepam, Diazepam, and Alprazolam XR. The analysis presents the weighted mean difference (WMD) point estimates with 95% confidence intervals (CIs) for each comparator, highlighting the overall effectiveness of Alprazolam (I² = 0.97, p < 0.01). The results suggest that Alprazolam may have superior therapeutic effects compared to its comparators.

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Between-Arm Differences in HAM-A Improvement: Alprazolam vs. Comparators in Clinical Study

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  1. 1 Figure S3: Forest Plot for Between-Arm Difference in HAM-A Improvement from Baseline to Final Evaluation WMD Point Estimate (95% CI) Study (Comparator Benzodiazepine) Meco et al.36 (Etizolam) Schweizer et al.39 (Lorazepam) 1 1 Charney & Woods.35 (Lorazepam) Noyes et al.37 (Diazepam) Dunner et al.9 (Diazepam) Pecknold et al.41 (Alprazolam XR) Overall (I2 = 0.97, p=<0.01) . Favours comparator Favours alprazolam 1 -2 -1 0 1 2 Difference in DHAM-A

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