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Doxorubicin Moa

Doxorubicin, often regarded by the trade name “adriamycin”, is a member of the anthracycline compounds derived from Streptomyces peucetius var. caesius in the 1960s. These compounds were given the name doxorubicin or daunorubicin. Doxorubicin and its derivatives, function by DNA helix intercalation, topoisomerase poisoning, free radical generation…, are still regarded as some of the most impactful chemotherapeutic antitumor agents.

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Doxorubicin Moa

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  1. Doxorubicin Moa www.creative-biolabs.com/adc

  2. Doxorubicin Moa Doxorubicin, often regarded by the trade name “adriamycin”, is a member of the anthracycline compounds derived from Streptomyces peucetius var. caesius in the 1960s. These compounds were given the name doxorubicin or daunorubicin. Doxorubicin and its derivatives, function by DNA helix intercalation, topoisomerase poisoning, free radical generation…, are still regarded as some of the most impactful chemotherapeutic antitumor agents.

  3. Doxorubicin Moa Doxorubicin is a 14-hydroxylated version of daunorubicin and is has been applied to the treatment of a broad range of both solid and liquid tumors. However, the appearance of drug resistance and possible side effects, for example, heart muscle injure after doxorubicin treatment, result in a narrow therapeutic window for doxorubicin-based cancer treatments.

  4. CONTENTS Doxorubicin mode of action (MOA) 1 Doxorubicin-based ADCs 2

  5. Doxorubicin mode of action (MOA) 1 A figure illustration of doxorubicin DNA intercalation (left, Biochim. Biophys. Acta., 2014) and doxorubicin induced topoisomerase II poisoning (right, Nat Rev Clin Oncol., 2015), major doxorubicin mode of actions that leads to DNA damage and cell death.

  6. Doxorubicin-based ADCs 2 Structures of a doxorubicin ADC and other doxorubicin derivatives that are potential candidates as ADC payloads. The ADC is comprised of a chimeric anti-LewisY cBR96 mAb conjugated with doxorubicin via an acid-labile hydrazone linker to release the payload inside the cytosome of targeted cancer cells, thereby increase the total efficacy of doxorubicin (Bioorg. Med. Chem. Lett., 2014).

  7. Contact us 45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-619-7922 Fax: 1-631-207-8356 Email: marketing@creative-biolabs.com

  8. THANKS END Creative Biolabs

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