'Creative biolabs' diaporamas de présentation

ADC Platform

ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and wide applications in treating various types of cancer, fungal or bacterial infections, cardiovascular disorders, and immune diseases. Creative Biolabs and our collaborators are equipped with state-of-the-art research and manufacturing facilities and our advanced technical platforms cover crucial stages in ADC development.

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ADC Payload

Antibody-drug conjugates (ADCs) are next-generation targeted anti-tumor agents that are constructed by the covalent coupling of a monoclonal antibody with a cytotoxic payload drug via a small molecular linker. As a key factor in an ADC, the payload drug dictates its efficacy.

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Duocarmycin

Duocarmycins are a series of natural products originally isolated from Streptomyces bacteria in 1988. They exhibit an impressively high cytotoxicity and are subsequently developed into anti-tumor agents. Duocarmycin analogues, among which CC-1065 and duocarmycin SA are the most widely used, represent a series of extremely powerful.

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The Optimization and Selection Strategies of ADC

ADC (antibody-drug conjugate) is a compound molecule consisting of an antibody that is linked to a bioactive cytotoxicity (anti-cancer agent) payload or drug. Antibody-drug conjugates are currently a major research field, mainly focused on oncology, but in other areas such as infectious diseases are also limited. The success of this targeted drug delivery depends on many factors, one of which is the performance of the linker to release the active drug moiety under appropriate conditions.

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Maytansinoid

Maytansine and its derivatives (named as maytansinoids in general) are members of the ansamycins superfamily and contains a 19-member macrocyclic lactams attached to a chlorinated benzene. Maytansine is originally isolated from an Ethiopian shrub Maytenus ovatus and exerts extremely high anti-mitotic potency.

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Developing Strategy for Next Generation of Antibody - Drug Conjugates

Comprised of a recombination monoclonal antibody and cytotoxic payloads through a linker, antibody drug conjugate (ADC) not only has highly cytotoxic antitumor effect of small molecule drugs, but also combines the high selectivity, stability and favorable pharmacokinetic characteristics of mAb.

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Akt inhibitor

Also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds. Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family.

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Antibody Fluorophore Probes

Fluorophores are a family of chemical compounds that can emit light upon the adsorption of energy from an excitation light source. For a certain fluorophore, there is a specific excitation and emission spectrum. Typically, the wavelengths of light that can cause the maximum excitation and be captured from the maximum emission (Excitation/Emission) are used to refer to a given fluorophore.

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Doxorubicin Moa

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car t

In a broad sense, cancer biomarker is an indicative of the presence of cancer in the body or a molecule secreted by a tumor or a specific response of the body to the presence of cancer. It is usually identifiable or measurable in the blood, urine or other convenient body fluids by PCR, ELISA, and other conventional immune assays.

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antibody conjugates

To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically reactive and can be used as conjugation sites. Scientists at Creative Biolabs are experienced in performing Lysine conjugation (amine reaction) as well as Cysteine conjugation (thiol reactions) to create ADCs using these endogenous sites. We are also expertise in exploiting Tyrosine conjugation approaches as another innovated endogens site for ADC development.

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car t therapy

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Introduction of Creative Biolabs, a US biotech company.

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Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world. Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer. We believe to build up a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. Our commitment to this long-term goal motivates us to deliver the highest quality results to our clients with speed.

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Basic Analysis on the Detection of Antibody

Basic Analysis on the Detection of Antibody

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Antibody Sequencing Is Available in Creative Biolabs

Antibody Sequencing Is Available in Creative Biolabs

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Antibody Sequencing Is Available in Creative Biolabs.pdf Uploaded Successfully

Generally speaking, antibodies and specific antigens possess high affinity, which plays a major role in the immune system response. Antibodies are connected with the occurrence of a variety of diseases, prevention, and development closely. Furthermore, the research toward antibodies has now become an important part of the research in life science. Links: Creative Biolabs: http://www.creative-biolabs.com/ Antibody Sequencing: http://www.creative-biolabs.com/next-generation-antibody-sequencing.html

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CAR T cell establish

Systematic T cell leukemia models at Creative Biolabs are established by implantation of luciferase-labeled Jurkat or K562 cells (Tn-MUC1 positive) into NSG mice via tail-vein injection.

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