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Proteomic. Ka-Lok Ng Asia University. Topics to be covered. Amino acids: the building blocks of proteins Dihedral angles (φandψ) in the backbone of biopolymers and the Ramachandran plots
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Proteomic Ka-Lok Ng Asia University
Topics to be covered • Amino acids: the building blocks of proteins • Dihedral angles (φandψ) in the backbone of biopolymers and the Ramachandran plots • Tertiary structures of proteins: all-a topologies, all-b topologies, b barrels, the Greek Key topology, and the Jellyroll Topology, and a/b topologies (a/b horseshoe). • Protein 1D, 2D and 3D databases: PDB, SCOP, CATH, DSSP, Uniprot • Physical methods of determining the three dimensional structure of protein • Protein folding in vivo and in vitro • Protein structure prediction: homology, threading, ab inito prediction • Protein-protein interaction network • Protein structure and molecular approach to medicine • X-ray and NMR • Discussion of articles
40% on quiz, classwork, homework, class attendance • Mid-term, oral presentation – 30%, final exam. – 30%, oral presentation
References • Orengo, Jones, and Thornton, Bioinformatics: genes, proteins, and computers. BIOS scientific Publishers (2003) • Baxevanis A. and Ouellette B.F. Francis. Bioinformatics. J. Wiley (2005) • Lesk A.M. Introduction to Protein structures Oxford University Press (2001).
