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Chronic Inflammation Dr : Hala El-sayed Mahmoud Lecturer of pathology

Chronic Inflammation Dr : Hala El-sayed Mahmoud Lecturer of pathology. 1- Chronic non-specific inflammation Different irritants produce inflammatory reaction of the same microscopic picture 2- Chronic specific inflammation

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Chronic Inflammation Dr : Hala El-sayed Mahmoud Lecturer of pathology

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  1. ChronicInflammationDr : Hala El-sayed Mahmoud Lecturer of pathology

  2. 1- Chronic non-specific inflammation Different irritants produce inflammatory reaction of the same microscopic picture 2-Chronic specific inflammation Each irritant produces inflammation of a characteristic microscopic picture Types of Chronic Inflammation

  3. Chronic non-specific inflammation

  4. Definition: A type of chronic inflammation characterized by focal accumulation of large number of macrophages together with lymphocytes, plasma cells, giant cells and fibroblasts forming tiny granules Granuloma

  5. 1-Infective granuloma a. Bacterial e.g.TB, leprosy & syphilis b. Parasitic e.g. Bilharziasis c. Fungal e.g. madura foot 2-Non-infective granuloma a. Silicosis and asbestosis b. Foreign body granuloma 3-Granuloma of unknown cause Sarcoidosis Types of Granulomas

  6. Tuberculous granuloma of the lung Granuloma

  7. TB in Lymph node

  8. Section in a lymph node shows multiple tubercles formed of : 1-Epithelioid cells having pale cytoplasm, round or oval vesicular nuclei and indistinct cell border 2- Langhan’s giant cells with large number of round nuclei arranged in the periphery as a circle or arch 3- Lymphocytes encircle the tubercle. Diagnosis: Tuberculosis of lymph node

  9. Laghan’s giant cells

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