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SPECIFIC OBJECTIVE

Efficacy of crude water extracts of selected plants against gastrointestinal helminthes in goats in Uganda 2012 Immaculate Nabukenya 1 , Betty Ayoo 1 , Rubaire-Akiiki 1 , Johan Höglund 2 1 Makerere University, Uganda and 2 Swedish University of Agricultural Sciences, Sweden. METHODS.

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SPECIFIC OBJECTIVE

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  1. Efficacy of crude water extracts of selected plants against gastrointestinal helminthes in goats in Uganda 2012Immaculate Nabukenya1, Betty Ayoo1, Rubaire-Akiiki1, Johan Höglund21Makerere University, Uganda and 2Swedish University of Agricultural Sciences, Sweden METHODS INTRODUCTION SPECIFIC OBJECTIVE • Gastrointestinal helminths especially nematodes are important endoparasites causing direct and indirect losses to goat farmers. • In Uganda, several ethnoveterinary practices including use of plants to treat helminthes in goats have been documented. • Following the farmers’ advice, we constituted crude water extracts at 65 mg/ml of Tephrosia vogelii and Vernonia amygdalina administered at 50 ml once to all 40 goats in Trial one (institutional farm). Albendazole 10% was by body weight at manufacturer’s doses. • In Trial two (individual farms), we used 115 mg/ml crude extracts; administered at 50 ml daily over three days to 20 goats per group with Albendazole 10% as control. • Fecal egg count reduction test was used to assess the efficacy with pre and post treatment egg counts at day 0, 8 and 15. To evaluate efficacy of crude water extracts of two farmer selected plants against gastrointestinal helminthes in goats from Mbarara and Rakai districts in Uganda. RESULTS • Albendazole 10% had the highest reduction in epg at 88% & 98% in Trial 1 & 2; V. amygdalina at 11 and 56%; T. vogelii at 49% & 60%. • Resistance to albendazole detected on institutional farm but not on small holder farms (88% vs 98% respectively). • Significantly different reductions were recorded for day 8 and day 15 post treatment evaluations (P=0.001) Fig. 1: Mean & 95% CI of epg in Trial 1 Fig. 2: Mean & 95% CI of epg in Trial 2 CONCLUSIONS & RECOMMENDATION • Tephrosia and Vernonia show considerable anthelmintic activity. • A dose response bio-activity observed in Trial 2 where we doubled the farmer recommended doses and treated the animals three consecutive days compared to Trial 1. • Further evaluation of albendazole resistance and anthelmintic efficacy of the two plants in vitro & in vivo Vernonia amygdalina Del Tephrosia vogelii Hook ACKNOWLEDGEMENTS • National Agricultural Research Organization, Mbarara ZARDI • Makerere University • Swedish University of Agricultural Sciences Supervisors Contact: Dr. Immaculate Nabukenya +256-772-606518 lennfaith@yahoo.com

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