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Supplemental Table 1. Valproic Acid levels in the serum of treated CLL patients

Supplemental Table 1. Valproic Acid levels in the serum of treated CLL patients. Supplemental Table 2. Absolute Lymphocyte values in treated CLL patient. O/S = Off Study, SD = Stable Disease, PR = Partial Response, PD = Progressive Disease 1. No further treatment required

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Supplemental Table 1. Valproic Acid levels in the serum of treated CLL patients

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  1. Supplemental Table 1. Valproic Acid levels in the serum of treated CLL patients Supplemental Table 2. Absolute Lymphocyte values in treated CLL patient. O/S = Off Study, SD = Stable Disease, PR = Partial Response, PD = Progressive Disease 1. No further treatment required 2. Discontinued due to fatigue 3. Discontinued due to anemia

  2. A. CLL1 CLL2 RPMI+0.5%BSA Hybridoma SF RPMI+10%FBS %SubG1 Events Days Days B. C. D. N/S N/S Mutated Unmutated Combination Index %Annexin V Positivity %SubG1 Events Synergy VPA+ FLU FLU E. 15- 100- 15- 15- 10- 70- 40- Figure S1

  3. A. B. C. D. Vehicles Fludarabine (5 μM) VPA (1 mM) VPA + Fludarabine XIAP Mcl-1 Fold Expression Fold Expression Figure S2

  4. 15- 40- Figure S3

  5. A. B. % Cells with Diffuse AO stain C. D. * ** FL3 GeoMean E. Vehicles CA074-Me %SbuG1 Events Figure S4

  6. A. Fold increase in H3 acetylation Days Figure S5

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