'Allelic association' diaporamas de présentation

Allelic association - PowerPoint PPT Presentation

Allelic Association and Transmission Disequilibrium Test

Allelic Association and Transmission Disequilibrium Test

Allelic Association and Transmission Disequilibrium Test. ????? ?????????? ??????? ??? (x 2641). Linkage Disequilibrium (allelic association). Def: nonrandom association of alleles at linked loci f (A, B)= f (A) x f (B). :. Haplotype.

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1.05k views • 90 slides
Allelic Association and Transmission Disequilibrium Test

Allelic Association and Transmission Disequilibrium Test

Allelic Association and Transmission Disequilibrium Test. ????? ?????????? ??????? ??? (x 2641). Linkage Disequilibrium (allelic association). Def: nonrandom association of alleles at linked loci f (A, B)= f (A) x f (B). :. Haplotype.

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1.17k views • 90 slides
Association Mapping

Association Mapping

Association Mapping. Lon Cardon University of Oxford. Outline. Association and linkage Association and linkage disequilibrium History and track record of association studies Challenges Example. Outline. Association and linkage Association and linkage disequilibrium

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866 views • 83 slides
Association Mapping

Association Mapping

Association Mapping. Benjamin Neale 19 th International Workshop on Twin Methodology 2006. Liberally sampled from talks by Lon Cardon and Shaun Purcell. Outline. Association and linkage Association and linkage disequilibrium History and track record of association studies Challenges

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870 views • 65 slides
Genetic Epidemiology M. Tevfik DORAK dorak/epi/genetepi.html

Genetic Epidemiology M. Tevfik DORAK dorak/epi/genetepi.html

Genetic Epidemiology M. Tevfik DORAK http://www.dorak.info/epi/genetepi.html. Approaches to the identification of susceptibility genes Rebbeck TR. Cancer 1999 ( www ). Palmer LJ. Webcast ( www ). GENETIC EPIDEMIOLOGIC RESEARCH METHODS.

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1.12k views • 64 slides
Gene mapping: Linkage and association methods

Gene mapping: Linkage and association methods

Disease gene mapping is one of the main purposes for genotyping Two major approaches: linkage and association analyses. Gene mapping: Linkage and association methods. Try to localize genes affecting specific phenotypes Search for: co-segregation of disease and marker alleles.

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1.43k views • 41 slides
Type 1 Error and Power Calculation for Association Analysis

Type 1 Error and Power Calculation for Association Analysis

Type 1 Error and Power Calculation for Association Analysis. Pak Sham & Shaun Purcell Advanced Workshop Boulder, CO, 2005. Statistical Tests. Standard test theory Type 1: Rejecting the null hypothesis when it is true ( ? ).

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727 views • 41 slides
Research Techniques Day Friday 16 th January, 2009

Research Techniques Day Friday 16 th January, 2009

Genetic Association of Disease Richard Mott Wellcome Trust Centre for Human Genetics (with some slides by Lon Cardon ). Research Techniques Day Friday 16 th January, 2009. Association Studies. Simplest design possible Correlate phenotype with genotype Candidate genes for specific diseases

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345 views • 28 slides
Inferences on human demographic history using computational Population Genetic models

Inferences on human demographic history using computational Population Genetic models

Inferences on human demographic history using computational Population Genetic models. Gabor T. Marth. Department of Biology Boston College Chestnut Hill, MA 02467. The current variation resource. The current public resource (dbSNP) contains over 10 million SNPs.

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211 views • 21 slides
Positional Cloning

Positional Cloning

LOD. Positional Cloning. Genetics. Chromosome Region. Association Study. Sib pairs. Genomics. Candidate Gene Selection/ Polymorphism Detection. Mutation Characterization/ Functional Annotation. Physical Mapping/ Sequencing. Netherton Syndrome Linkage.

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572 views • 10 slides
Positional Cloning

Positional Cloning

LOD. Positional Cloning. Genetics. Chromosome Region. Association Study. Sib pairs. Genomics. Candidate Gene Selection/ Polymorphism Detection. Mutation Characterization/ Functional Annotation. Physical Mapping/ Sequencing. Netherton Syndrome Linkage.

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592 views • 10 slides

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