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Metabolisme Nukleotida

Metabolisme Nukleotida. Makromolekul/Polinukleotida: DNA Nukleotida: dTTP, dCTP, dGTP, dATP Makromolekul/Polinukleotida: RNA Nukleotida: CTP, UTP, GTP, ATP. DNA. RNA, metabolit aktif, koenzim. DNA. dTTP dCTP. CTP. UTP. GTP. ATP. dGTP dATP. dTMP. dGDP dADP.

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Metabolisme Nukleotida

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  1. Metabolisme Nukleotida

  2. Makromolekul/Polinukleotida: DNA • Nukleotida: dTTP, dCTP, dGTP, dATP • Makromolekul/Polinukleotida: RNA • Nukleotida: CTP, UTP, GTP, ATP

  3. DNA RNA, metabolit aktif, koenzim DNA dTTP dCTP CTP UTP GTP ATP dGTP dATP dTMP dGDP dADP dUDP dCDP CDP UDP GDP ADP dUMP dCMP UMP GMP AMP dUTP Inosinat (IMP) Karbamoil Fosfat PRPP Asam amino Gula 5C Overview metabolisme nukleotida

  4. Biosintesis nukleotida purin • Dimulai dari gula ribosa • Fosforilasi • Biosintesis basa Ribosa-5P + ATP 

  5. Pertumbuhan Basa Purin

  6. Biosintesis IMP

  7. Biosintesis ATP dan GTP GMP + ATP  GDP + ADP GDP + ATP  GTP + ADP AMP + ATP  2ADP ADP + Pi  ATP

  8. Biosintesis Nukleotida Pirimidin • Pertumbuhan basa • Penggabungan Gula dalam bentuk PRPP

  9. Biosintesis Nukleotida deoksiribosa

  10. Biosintesis nukleotida timin

  11. Katabolisme • Nukleotida sebagian besar didegradasi dan digunakan kembali • Terjadi intraselular • Enzim endonuklease atau eksonuklease memotong ikatan fosfodiester • Enzim fosfodiesterase memotong sampai dihasilkan nukleosida monofosfat untuk dapat digunakan kembali dalam biosintesis

  12. Degradasi nukleotida purin menghasilkan asam urat • Degradasi pirimidin menghasilkan asam amino (alanin) dan urea

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