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Chapter 43: Immune System Antibodies Table

Chapter 43: Immune System Antibodies Table. Fig. 43-20. Class of Immuno- globulin (Antibody). Distribution. Function. First Ig class produced after initial exposure to antigen; then its concentration in the blood decl ines. Promotes neutraliza- tion and cross- linking of antigens;

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Chapter 43: Immune System Antibodies Table

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  1. Chapter 43: Immune SystemAntibodies Table

  2. Fig. 43-20 Class of Immuno- globulin (Antibody) Distribution Function First Ig class produced after initial exposure to antigen; then its concentration in the blood declines Promotes neutraliza- tion and cross- linking of antigens; very effective in complement system activation IgM (pentamer) J chain IgG (monomer) Most abundant Ig class in blood; also present in tissue fluids Promotes opsoniza- tion, neutralization, and cross-linking of antigens; less effec- tive in activation of complement system than IgM Only Ig class that crosses placenta, thus conferring passive immunity on fetus Present in secretions such as tears, saliva, mucus, and breast milk IgA (dimer) Provides localized defense of mucous membranes by cross-linking and neutralization of antigens J chain Presence in breast milk confers passive immunity on nursing infant Secretory component IgE (monomer) Present in blood at low concen- trations Triggers release from mast cells and basophils of hista- mine and other chemicals that cause allergic reactions IgD (monomer) Present primarily on surface of B cells that have not been exposed to antigens Acts as antigen receptor in the antigen-stimulated proliferation and differentiation of B cells (clonal selection) Trans- membrane region

  3. Fig. 43-20a Class of Immuno- globulin (Antibody) Distribution Function First Ig class produced after initial exposure to antigen; then its concentration in the blood declines Promotes neutraliza- tion and cross- linking of antigens; very effective in complement system activation IgM (pentamer) J chain

  4. Fig. 43-20b Class of Immuno- globulin (Antibody) Distribution Function IgG (monomer) Most abundant Ig class in blood; also present in tissue fluids Promotes opsoniza- tion, neutralization, and cross-linking of antigens; less effec- tive in activation of complement system than IgM Only Ig class that crosses placenta, thus conferring passive immunity on fetus

  5. Fig. 43-20c Class of Immuno- globulin (Antibody) Distribution Function IgA (dimer) Present in secretions such as tears, saliva, mucus, and breast milk Provides localized defense of mucous membranes by cross-linking and neutralization of antigens J chain Presence in breast milk confers passive immunity on nursing infant Secretory component

  6. Fig. 43-20d Class of Immuno- globulin (Antibody) Distribution Function IgE (monomer) Present in blood at low concen- trations Triggers release from mast cells and basophils of hista- mine and other chemicals that cause allergic reactions

  7. Fig. 43-20e Class of Immuno- globulin (Antibody) Distribution Function IgD (monomer) Present primarily on surface of B cells that have not been exposed to antigens Acts as antigen receptor in the antigen-stimulated proliferation and differentiation of B cells (clonal selection) Trans- membrane region

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