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ADAM metallopeptidase domain 17

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.

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ADAM metallopeptidase domain 17

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  1. adam17 adam17 Official Full Name Official Full Name ADAM metallopeptidase domain 17 Background Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008] Synonyms Synonyms ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; Recombinant Recombinant Prot Proteins eins  Cell & Tissue Lysates Cell & Tissue Lysates Assay Kits Assay Kits Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price Adam17- 522M Recombinant Mouse A Disintegrin And Metallopeptidase Domain 17, His-tagged NS0 Mouse His +Inquiry ADAM17- 278H Recombinant Human ADAM17 Protein, GST-tagged Wheat Germ Human GST +Inquiry

  2. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price ADAM17- 593H Recombinant Human ADAM17 Baculovirus- Insect Cells Human N/A +Inquiry ADAM17- 7114H Recombinant Human ADAM17 protein, His-tagged E. coli Human His +Inquiry Adam17- 256M Recombinant Mouse Adam17 protein, His-tagged HEK293 Mouse His +Inquiry ADAM17- 501R Recombinant Rat ADAM17 Protein Mammalian Cells Rat His +Inquiry Adam17- 7115R Recombinant Rat Adam17 protein, His & T7-tagged E. coli Rat His/T7 +Inquiry Adam17- 8788R Recombinant Rat Adam17, His tagged HEK293 Rat His +Inquiry ADAM17- 1867C Recombinant Chicken ADAM17 Mammalian Cells Chicken His +Inquiry ADAM17- 592H Recombinant Human ADAM Metallopeptidase Domain 17, His-tagged Baculovirus- Insect Cells Human His +Inquiry Involved Pathway ADAM17 involved in several pathways and played different roles in them. We selected most pathways ADAM17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same

  3. pathway with ADAM17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein Notch signaling pathway ADAM17A; LNX1; HER9; JAG2B; NOTCH3; HER15.1; MFAP5; RBPJB; MFAP2; JAG1A Alzheimers disease MAPT; BAD; GNAQ; GSK3B; NDUFS5; ATP2A3; COX6C; ATP5E; ATP5O; CALML3 Epithelial cell signaling in Helicobacter pylori infection MET; TCIRG1; ATP6V1E1; ATP6V0D1; CXCR2; CCL5; ATP6V1A; PLCG2; ATP6V0C; ATP6V1G1 Protein Function ADAM17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM17 itself. We selected most functions ADAM17 had, and list some proteins which have the same functions with ADAM17. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function Notch binding Related Protein Related Protein C8orf4; NCOR2; NOV; DTX1; JAG1B; JAG1; JAG2B; CHAC1; NOTCH1; GALNT11 Function Function PDZ domain binding Related Protein Related Protein CADM1; ATP2B4; DTNA; F11R; ACCN3; PARK2; Apba1; PLEKHA2; ATP2B2; PDZK1 Function Function SH3 domain binding Related Protein Related Protein WIPF3; SGIP1; SHANK1; EPS15; NOXA1; ABI2; PTPN22; SH3BP1; PARK2; DNM2 Function Function integrin binding Related Protein Related Protein FERMT3; TGFBI; DST; THBS4; PXN; EDIL3; ACTN4; L1CAM; ICAM5; ADAMTS13 Function Function interleukin-6 receptor binding Related Protein Related Protein ADAM17; IL6; PYCARD; CNTF; ERAP1 Function Function metalloendopeptidase activity Related Protein Related Protein ECEL1; ADAM10B; TLL1; ADAM2; ADAMTS3; HE1B; ADAM20; UQCRC2B; YBEY; ADAM22 Function Function metallopeptidase activity Related Protein Related Protein C6AST1; MMP23BB; ADAM1B; BMP1A; CNDP1; ERMP1; CPD; ANPEPA; STAMBP; STAMBPL1 Function Function protein binding

  4. Related Protein Related Protein NTRK3; KHDC1B; VCAN; PCBD2; AGO2; TRIM2; BEX1; CCDC170; NDUFS1; GADD45A Function Function zinc ion binding Related Protein Related Protein ING2; ADAM2; SNAI1A; ZNF3; TRIM8; GLO1; TRIM65; LHX8A; EWSR1; OTUD7A Interacting Protein ADAM17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM17. DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2 ADAM17 Related Articles Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell renal cell carcinomas: Implication for patients' prognosis. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014). Arenaccio, C; Chiozzini, C; et al. Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).

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