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glucosidase, beta, acid

glucosidase, beta, acid ;glucosidase, beta, acid

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glucosidase, beta, acid

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  1. gba  Official Full Name  glucosidase, beta, acid  Background  This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.  Synonyms  GBA; glucosidase, beta, acid; GLUC, glucosidase, beta; acid (includes glucosylceramidase) , glucosylceramidase; glucosylceramidase; GBA1; alglucerase; imiglucerase; acid beta-glucosidase; beta-glucocerebrosidase; lysosomal glucocerebrosidase; D-glucosyl  Recombinant Proteins   Cell & Tissue Lysates Therapeutic Proteins Involved Pathway GBA involved in several pathways and played different roles in them. We selected most pathways GBA participated on our site, such as Other glycan degradation, Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Related Protein Other glycan degradation GLB1; NEU2; MANBA; HEXDC; FUCA2; NEU1; NEU3.5; FUCA1.1; MAN2B2; NEU3.3 Sphingolipid metabolism GBA2; GAL3ST1A; LASS4; NEU1; NEU3.2; FA2H; GALCB; ENPP7; ASAH2; ASAH1

  2. Metabolic pathways SPHK2; MTMR4; PCYT2; ITPK1; DAK; ST8SIA1; PDXKA; AGXT; PIGU; ALDH3B2 Lysosome AP3B2; AP3B1; SLC11A1; DNASE2A; FUCA1; GNPTAB; NEU1; GALCA; IGF2R; CTSH Protein Function GBA has several biochemical functions, for example, glucosylceramidase activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA itself. We selected most functions GBA had, and list some proteins which have the same functions with GBA. You can find most of the proteins on our site. Function Related Protein Function glucosylceramidase activity Related Protein GBA2; GBA Function protein binding Related Protein IMP4; DPEP1; LRRC8C; HSPA2; LDHAL6B; Artn; RNF14; MCC; THEMIS2; KMT2E Function receptor binding Related Protein GSTM2; DIAPH1; WNT11R; CADM3; RIPK2; PAOX; FGF1B; HACL1; LBP; CYTL1 Interacting Protein GBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA. Scarb2; pi3p; SCAMP3; TOP3B; A2M; cona_canen; HSPD1; HSP90B1; ATP5J; CANX; ATP6V1A; SKIV2L2; CCT3; CCT8; RPS6KA3; FMR1; ZMYND11; DHCR24; RNF20; ZCCHC8 GBA Related Articles Sinclair, G; Pfeifer, TA; et al. Secretion of human glucocerebrosidase from stable transformed insect cells using native signal sequences. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 84:148-156(2006). Favalli, EG; Varenna, M; et al. Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 23:247- 250(2005).

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