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vascular cell adhesion molecule 1

Human Vascular Cell Adhesion Molecule-1 is a 100 - 110 kDa, 715 amino acid type I transmembrane glycoprotein typically characterized by the presence of seven C2-type immunoglobulin domains.

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vascular cell adhesion molecule 1

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  1. vcam1 vcam1 Official Full Name Official Full Name vascular cell adhesion molecule 1 Background Background Human Vascular Cell Adhesion Molecule-1 is a 100 - 110 kDa, 715 amino acid type I transmembrane glycoprotein typically characterized by the presence of seven C2-type immunoglobulin domains. Its extracellular region is 674 aa in length, followed by a 22 aa transmembrane segment and a 19 aa cytoplasmic tail. In the extracellular region, there are multiple N-linked glycosylation sites, and each C2 domain is closed by a disulfide bridge. There is considerable interspecies VCAM-1 homology, with mouse and rat VCAM-1 showing approximately 75% aa identity to human VCAM-1. Notably, the short 19 aa cytoplasmic tail is absolutely conserved, mouse to human to rat. Cells expressing mouse VCAM-1 bind both mouse and human leukocytes, and this reflects their high degree of aa identity. A number of variants of VCAM-1 are known to occur, all of which are likely the result of alternate gene splicing. In particular, a human six Ig domain molecule is known, and in rabbits, an eight Ig domain form has been identified. There is also a three-C2 domain, 43 kDa GPI-linked form of VCAM-1. Although it binds known VCAM-1 ligands, its function is unclear. Cells known to express VCAM-1 include neurons, endothelial cells, smooth muscle cells, fibroblasts and macrophages. Soluble VCAM-1 has been identified in culture supernates, blood, and cerebrospinal fluid. In vitro, basal levels of VCAM-1 shedding by unstimulated NIH3T3 cells appear to partially require metalloproteinase activity, while PMA-induced shedding is dependent upon the proteolytic activity of TACE/ADAM17. Functionally, VCAM-1 binds to both 4 1 and 4 7 integrins. These integrins are expressed on a variety of cells, with VLA-4 found on all leukocytes with the exception of neutrophils. Because of this, VCAM- 1/VCAM-1 ligand interactions are undoubtedly key events in the rate and timing of leukocyte extravasation. Other roles proposed for VCAM-1 include the regulation of osteoclastogenesis via a cell-to-cell contact mechanism and the induction of sickle cell adherence to vascular endothelial cells during hypoxemia. The Human sVCAM-1 Immunoassay is a 2 hour solid-phase ELISA designed to measure human sVCAM-1 in cell culture supernates, serum, and plasma. It contains CHO cell-expressed recombinant human sVCAM-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human sVCAM-1 showed linear curves that were parallel to the standard curves obtained using the kit standards. These results

  2. indicate that the Human sVCAM-1 immunoassay kit can be used to determine relative mass values for naturally occurring sVCAM-1. Synonyms Synonyms VCAM1; vascular cell adhesion molecule 1; INCAM-100; Vascular cell adhesion protein 1 precursor; CD-10^6 antigen; CD10^6; DKFZp779G2333; MGC99561; CD10^6 antigen; OTTHUMP00000012650; OTTHUMP00000012651; L1CAM; V-CAM 1; CD106; Vcam-1 Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysate Cell & Tissue Lysates s Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price VCAM1- 1793MA Recombinant Mouse VCAM1 protein, MIgG2a Fc-tagged, APC labeled CHO Cells Mouse MIgG2a Fc +Inquiry VCAM1- 1793MP Recombinant Mouse VCAM1 protein, MIgG2a Fc-tagged, R-PE labeled CHO Cells Mouse MIgG2a Fc +Inquiry VCAM1- 1794MA Recombinant Human VCAM1 protein, HIgG1 Fc-tagged, APC labeled CHO Cells Human HIgG1 Fc +Inquiry VCAM1- 1794MP Recombinant Human VCAM1 protein, HIgG1 Fc-tagged, R- PE labeled CHO Cells Human HIgG1 Fc +Inquiry Vcam1- 2313MA Recombinant Mouse Vcam1 protein, Fc- HEK293 Mouse FC/His +Inquiry

  3. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price His-tagged, APC labeled Vcam1- 2313MP Recombinant Mouse Vcam1 protein, Fc- His-tagged, R-PE labeled HEK293 Mouse FC/His +Inquiry VCAM1- 71HA Recombinant Human VCAM1 protein, Fc- tagged, APC labeled HEK293 Human Fc +Inquiry VCAM1- 71HP Recombinant Human VCAM1 protein, Fc- tagged, R-PE labeled HEK293 Human Fc +Inquiry VCAM1- 117H Recombinant Human VCAM1 Protein, MYC/DDK-tagged HEK293 Human MYC/DDK +Inquiry VCAM1- 170H Recombinant Human VCAM1 protein, His- tagged NS0 Human His +Inquiry VCAM1- 1794M Recombinant Human VCAM1, HIgG1 Fc- tagged CHO Human Fc +Inquiry VCAM1- 179H Recombinant Human VCAM1 protein, T7- tagged E. coli Human T7 +Inquiry

  4. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price VCAM1- 191H Recombinant Human VCAM1 Protein HEK293 Human +Inquiry VCAM1- 2325H Recombinant Human VCAM1, His tagged HEK293 Human His +Inquiry VCAM1- 31199TH Recombinant Human VCAM1, His-tagged E. coli Human His +Inquiry VCAM1- 3142H Recombinant Human VCAM1, His tagged HEK293 Human His +Inquiry VCAM1- 6796H Recombinant Human Vascular Cell Adhesion Molecule 1, His-tagged E. coli Human His +Inquiry VCAM1- 68H Recombinant Human VCAM1 Protein, His- tagged, Bioactivity Validated Insect cells Human His +Inquiry VCAM1- 71H Recombinant Human VCAM1, Fc tagged HEK293 Human Fc +Inquiry Vcam1- 1784M Recombinant Mouse Vascular Cell Adhesion Molecule 1 NS0 Mouse N/A +Inquiry VCAM1- 1793M Recombinant Mouse VCAM1, MIgG2a Fc- tagged CHO Mouse Fc +Inquiry

  5. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price Vcam1- 188M Recombinant Mouse Vcam1 protein, His- tagged Insect cell Mouse His +Inquiry Vcam1- 2313M Recombinant Mouse Vcam1, Fc-His tagged HEK293 Mouse FC/His +Inquiry Vcam1- 2771M Recombinant Mouse Vcam1 protein, His- tagged E. coli Mouse His +Inquiry Vcam1- 2772M Recombinant Mouse Vcam1 protein, His- tagged E. coli Mouse His +Inquiry Vcam1- 4012M Recombinant Mouse Vcam1, His tagged HEK293 Mouse His +Inquiry Vcam1- 4013M Recombinant Mouse Vcam1, His-tagged HEK293 Mouse His +Inquiry Vcam1- 491M Recombinant Mouse Vcam1, Fc Chimera NSO cells Mouse Fc Chimera +Inquiry Vcam1- 2773R Recombinant Rat Vcam1 protein, His & T7-tagged E. coli Rat His/T7 +Inquiry VCAM1- 6505R Recombinant Rat VCAM1 Protein Mammalian Cells Rat His +Inquiry

  6. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price VCAM1- 1534R Recombinant Rhesus Monkey VCAM1 Protein HEK293 Rhesus monkey +Inquiry VCAM1- 1535R Recombinant Rhesus Monkey VCAM1 Protein, hIgG1- tagged HEK293 Rhesus monkey hIgG1 +Inquiry VCAM1- 1536R Recombinant Rhesus Monkey VCAM1 Protein, hIgG4- tagged HEK293 Rhesus monkey hIgG4 +Inquiry VCAM1- 2775R Recombinant Rhesus monkey VCAM1 protein, His & T7- tagged E. coli Rhesus monkey His/T7 +Inquiry VCAM1- 2770D Recombinant Dog VCAM1 protein, His- tagged E. coli Dog His +Inquiry VCAM1- 2774R Recombinant Rabbit VCAM1 protein, His & S-tagged E. coli Rabbit His/S +Inquiry VCAM1- 5452Z Recombinant Zebrafish VCAM1 Mammalian Cells Zebrafish His +Inquiry VCAM1- 1695H Recombinant Human Vascular Cell Adhesion Molecule 1 NS0 Human N/A +Inquiry

  7. Involved Pathway VCAM1 involved in several pathways and played different roles in them. We selected most pathways VCAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein NF-kappa B signaling pathway CCL13; GM1987; BLNK; BCL2; ICAM1; GM13304; PLCG1; PLAU; SYK; LTB Cell adhesion molecules (CAMs) SELL; CLDN18; NEGR1; HLA-DRB4; CADM1A; JAM2A; PVRL3; PVRL1; CLDNJ; SDC1 TNF signaling pathway CASP7; MAP3K5; PIK3CG; NFKBIA; LTA; MAPK11; FAS; CXCL10; TAB2; MAP2K6 Leukocyte transendothelial migration ICAM1; VASP; CLDN2; VAV2; MYLPF; RAC1; ACTN1; CLDN20; MYL2; NCF2 African trypanosomiasis IFNG; SELE; HBB; F2RL1; FAS; HPR; IL18; HBA2; PRKCB; HBB-B1 Malaria CD81; IL-8; MET; ITGAL; KLRK1; KLRC4-KLRK1; IL12A; Ccl12; CCL2; CD40LG HTLV-I infection FZD9; PTTG2; XIAP; LTA; VDAC1; POLE4; CDC16; VDAC2; NFATC2; LCK Protein Function VCAM1 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, primary amine oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCAM1 itself. We selected most functions VCAM1 had, and list some proteins which have the same functions with VCAM1. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function cell adhesion molecule binding Related Protein Related Protein PVRL1A; ITGA4; JUP; CXADR; ITGB1; PVRL3; NRXN2; NLGN1; PKP3; NLGN3 Function Function integrin binding Related Protein Related Protein PTPN2; FN1A; GFAP; LAMB2; ITGA5; ADAM17; WISP1; FBLN1; ICAM2; CALR

  8. Function Function primary amine oxidase activity Related Protein Related Protein ABP1; MAOB; AOC2; AOC1; AOC3; MAOA; VCAM1 Interacting Protein VCAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VCAM1. ITGB1; ZYX; TLN1; PSMD11 VCAM1 Related Articles Almeda, D; Wang, BR; et al. Minimizing antibody surface density on liposomes while sustaining cytokine-activated EC targeting. BIOMATERIALS 41:37-44(2015). Marschall, AL; Single, FN; et al. Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies. MABS 6:1394-1401(2014).

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