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Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array

Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array Chu Chuan Liu 1,2 , Shih-Chung B. Lo 1 , Matthew T. Freedman 1, John Kula 3 , Bob Lasser 3 , Marvin E. Lasser 3 , Paul Wang 4 , and Yue Wang 2 1. ISIS Center, Georgetown University Medical Center, Washington, DC

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Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array

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  1. Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array Chu Chuan Liu1,2, Shih-Chung B. Lo1, Matthew T. Freedman1, John Kula3, Bob Lasser3, Marvin E. Lasser3 , Paul Wang4, and Yue Wang2 1. ISIS Center, Georgetown University Medical Center, Washington, DC 2. Computational Bioinformatics and Bioimaging Laboratory (CBIL), Virginia Polytechnic Institute and State University (Virginia Tech), VA 3. Imperium Inc., Silver Spring, MD 4. MRI Center, Howard University, Washington DC

  2. Contents • New piezoelectric CMOS sensor array (Model I400). • Dynamic range of the I400 chip. • Preliminary studies using transmission and reflective geometries : • Finger images. • Breast phantom images (CIRS model 52). • Bone fractures (reflective mode) • Small animal studies (heart motion & body).

  3. Transmission Ultrasound – Data Acquisition PC Image Capture Large unfocused Compound Lens source DSP Frame Grabber User Interface/ Delay for Water Image Path Processing Sensor array Target (breast with lesion) Pulser PC Controlled

  4. Hybrid Microelectronic Sensor Array Bond Wires Die Piezoelectric Coating PGA Carrier Schematic of the array A 128 × 128 assembled array

  5. A Compact Laboratory System Detecting System Component Transducer

  6. Reflective System Design Transducer Sensor (inside) Beam Splitter

  7. Handheld System

  8. Laboratory Setup

  9. System Performance

  10. Use a Step Wedge for the Evaluation of Dynamic Range Attenuation : 0.7dB/cm/MHz +- 0.07dB/cm/MHz

  11. Dynamic Range (5MHz) 11.6 dB 16.1 dB 20.6 dB 25.1dB 29.6dB 34.1dB 38.6dB 43.1dB 47.6dB 52.1 dB 56.6dB 61.1dB I100 chip (average 32) I400 chip (1 frame) We found that the dynamic range of the I400 sensor is about 70dB.

  12. Finger Images (5MHz) Distal interphalangeal joint Tendon of pollicis longus Extensor tendon

  13. Finger Images (7.5MHz)

  14. Breast Cysts and Masses (7.5MHz) An old CIRS phantom (model 52)

  15. Bone Fractures Experiment (5MHz) Reflective ultrasound setup

  16. A A C C B B A A B B St St D D A A C C B B C C D D Sb Sb D D ~500 mm Bone Fractures (Reflective Mode)

  17. Small Animal Study

  18. Mouse Anatomy

  19. MRI System (4.7 T)

  20. MRI Result (Front to Back)

  21. MRI Result (Whole Body)

  22. Mouse Imaging using the PE-CMOS

  23. Mouse Body & Heart Motion Movies • Three movie shows: • Whole mouse body movie operated at 5 MHz. • Mouse heart motion movie operated at 5 MHz. • Mouse heart motion movie operated at 3.5 MHz.

  24. Conclusions • The new ultrasound sensor array (I400) shows a dynamic range up to 70dB. • The system (transmission and reflective modes) has spatial resolution up to 350mm. • In the study of mice (with fur), we found that the heart motion can be captured. Lower frequency (3.5MHz) ultrasound shows better penetration for the chest region of the mouse. Both frequency and power were not optimized for the chest and abdomen regions. • We are developing image composition method (hardware & software) to integrate images for a large FOV.

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