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Compound Library Screening

Compound Library Screening for students,scholars,researchers...

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Compound Library Screening

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  1. Compound Library Screening

  2. Hit Identification Finding active compounds targeting a biological target is the first step in a drug discovery project, a process known as hit identification, and it can be challenging. In drug discovery programs, faster progress and lower attrition rates can be achieved by obtaining high-quality hits. There are many approaches to achieve this goal, from traditional high-throughput screening to virtual screening, fragment-based technology to high content screening. Creative Biostructure offers a range of customized solutions to help you succeed in the hit identification process. Our team will design a strategy for the project based on the nature of the project and the information available and the approaches we provide can be applied individually or in parallel.

  3. MagHelix™ Library Design and Preparation

  4. The screening library is a significant tool for lead compound discovery and selecting the right screening set can greatly increase the speed and ultimate success of the drug development program. Creative Biostructure has rich compound library resources, which can be applied to high-throughput screening (HTS), in silico virtual screening, fragment-based screening (FBS), and high-content screening (HCS). Each library can be used for individual screening or combined screening with other libraries, allowing a tailored approach to project requirements to maximize the coverage of the chemical space and the chance of finding hits.

  5. We have assembled some relevant focused/diverse screening libraries for hit screening. These libraries cover research areas (such as tumor and epigenetics), signal pathways (such as TGFβ, mTOR, and NF-κB), and hot protein targets (such as GCPRs, kinases and ion channels). Regardless of the level of known information about the target, and whatever screening technique you wish to choose, Creative Biostructure can design a focused and structurally diverse screening library to meet your needs and budget.

  6. References • Silva-Santisteban M C.; et al. Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. PLoS One. 2013, 8(6): e65689. • Oliveira L M.; et al. Virtual screening for the selection of new candidates to trypanosoma cruzi farnesyl pyrophosphate synthase inhibitors. Journal of the Brazilian Chemical Society. 2018, 29(12): 2554-2568.

  7. Related Services: • Lead Optimization and Preclinical Development • Natural Product Identification and Production • Hit to Lead

  8. Excerpt from: https://drug-discovery.creative-biostructure.com/hit-identification-p20

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