The Role of Genomic Profiling in Personalisation

1. The Role of Genomic Profiling in Personalised Cancer Treatment The Role of Genomic Profiling in Personalised Cancer Treatment Genomic profiling is revolutionising cancer treatment by enabling the development of personalised and targeted therapies tailored to each patient’s specific genetic makeup. By analysing a tumour’s DNA, doctors can identify unique genetic mutations that drive cancer growth, allowing for more e?ective and customised treatment plans. This blog will explain how genomic profiling works, its numerous benefits, and who should consider this advanced diagnostic approach to optimise their cancer treatment. What Is Genomic Profiling in Cancer? Genomic profiling is an advanced diagnostic approach that examines genetic mutations in cancer cells. Unlike traditional biopsy testing, which focuses on the physical

2. characteristics of a tumour, genomic profiling studies tumour DNA to understand how cancer behaves at a molecular level. Through DNA sequencing, oncologists gain insights into the genetic alterations driving cancer growth, enabling a more precise and targeted approach to treatment. How Genomic Profiling Helps Personalise Cancer Treatment Traditional cancer treatments often involve a trial-and-error approach, but genomic profiling allows for more precise treatment selection by identifying specific genetic mutations responsible for tumour growth. This approach o?ers: Precision Medicine – Treatments tailored to a patient’s unique cancer profile. Targeted Therapies – Medications designed to attack cancer cells with specific genetic changes. Reduced Side E?ects – A more e?ective approach that minimises unnecessary treatments. By understanding a tumour’s genetic blueprint, doctors can recommend therapies that are more likely to succeed, avoiding ine?ective or overly aggressive treatments. Step-by-step Process: Consultation – An oncologist or genetic specialist assesses the need for genomic testing. Sample Collection – A tumour biopsy or blood sample is taken for analysis. DNA Sequencing & Analysis – The sample is examined in a laboratory to identify genetic mutations. Report Generation – A detailed report provides targeted treatment recommendations. Personalised Treatment Planning – Oncologists use the findings to customise a treatment approach. Who Should Consider Genomic Profiling? For patients with advanced, rare, or recurrent cancers, traditional treatments may not always be e?ective. Genomic profiling o?ers an opportunity to explore alternative treatment options that are better suited to the unique genetic makeup of their cancer. This powerful tool is especially useful for individuals whose cancer has not responded well to conventional therapies, providing them with new possibilities for treatment that are targeted and more precise. If standard treatments have not yielded the desired results, genomic profiling can o?er new possibilities by identifying targeted therapies.

3. Types of Treatments Guided by Genomic Profiling Once genomic profiling identifies specific genetic mutations in a tumour, doctors can choose from a variety of treatments tailored to those mutations. These treatment options, including targeted therapies, immunotherapies, and participation in clinical trials, are all based on the tumour’s unique genetic profile, o?ering the best chance for successful treatment outcomes. The ability to select therapies with the highest likelihood of success is one of the key advantages of personalised cancer care. Key Benefits of Genomic Profiling for Cancer Patients Genomic profiling o?ers several advantages over traditional cancer treatment methods: More E?ective Treatments – Patients receive therapies tailored to their tumour’s genetic makeup. Lower Risk of Side E?ects – Personalised treatments minimise damage to healthy cells. Access to Immunotherapy – Identifies patients who may benefit from immune- based treatments. Predicts Treatment Response – Helps determine if chemotherapy or radiation will be e?ective. This personalised approach increases the chances of successful treatment and improves patient outcomes. Challenges and Limitations of Genomic Profiling Despite its benefits, genomic profiling does have some limitations: Not All Cancers Have Actionable Mutations – Some tumours do not contain genetic changes that can be targeted with existing therapies. Cost and Insurance Considerations – Genomic testing can be expensive, and coverage varies by provider. Ongoing Research Required – New mutations and treatments are constantly being discovered, requiring continuous advancements in precision oncology. While genomic profiling is a powerful tool, it works best when combined with expert medical guidance. Bottom Line Genomic profiling is revolutionising cancer treatment by introducing precision medicine, moving away from a one-size-fits-all approach. By analysing the unique

4. genetic mutations within a tumour, this advanced technique helps doctors select targeted therapies that are more e?ective and less harmful than traditional treatments. It minimises trial-and-error in treatment selection, reducing unnecessary side e?ects while improving patient outcomes. With genomic insights, patients receive personalised care, increasing the likelihood of successful treatment and better long-term health management. Discover Precision Oncology Solutions with Neeli Genetics What if you could receive a treatment plan based on your tumour’s unique genetic makeup? At Neeli Genetics Hyderabad, we specialise in genomic profiling that enables precision oncology, ensuring you get the most e?ective treatment. Our advanced testing solutions empower you to take charge of your health and optimise your treatment strategy. Book a consultation today and explore personalised cancer treatment options with our state-of-the-art genomic diagnostics.