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KEY CONCEPT Cell cycle regulation is necessary for healthy growth. PowerPoint Presentation
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KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

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KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

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  1. KEY CONCEPTCell cycle regulation is necessary for healthy growth.

  2. Internal and external factors regulate cell division. • External factors include physical and chemical signals. • Cell to cell contact • Most mammal cells form a single layer in a culture dish and stop dividing once they touch other cells. • Growth factors are proteins that stimulate cell division.

  3. Two of the most important internal factors are kinases and cyclins. • External factors trigger internal factors, which affect the cell cycle.

  4. webbed fingers • Apoptosis is programmed cell death. • a normal feature of healthy organisms • caused by a cell’s production of self-destructive enzymes • occurs indevelopmentof infants • Tadpoles to frogs: lose their tail

  5. normal cell cancer cell bloodstream Cell division is uncontrolled in cancer. • Cancer cells form disorganized clumps called tumors. • Benign tumors remain clustered and can be removed. • Generally considered non-cancerous • Malignant tumors metastasize, or break away, and can form more tumors.

  6. Cancer cells do not carry out necessary functions. • Cancer cells come from normal cells with damage to genes involved in cell-cycle regulation. • Don’t stick together to make tissues.

  7. Carcinogens are substances known to promote cancer. • Examples: tobacco (smoking/dipping), chemicals, UV light, HPV • Standard cancer treatments typically kill both cancerous and healthy cells.

  8. Mouth cancer – probably due to snuff

  9. HeLa cancer cells • Named for Henrietta Lacks • She was a very poor black lady from the south in the 1940s and who died from cervical cancer in 1951 • Because she was poor, uneducated, and black, she received almost no treatment for her cancer. (Which probably would have been fatal at that time anyway.) • Her cancer cells were taken from the biopsy and found to be able to grow indefinitely in labs, thus they were called “immortal.” • Researchers made millions of dollars from her cells, but her family received nothing.

  10. Henrietta Lacks 1920-1951 • http://www.youtube.com/watch?v=y38pgPY6Zq0