Laboratory Automation & Instrumentation Power Protection Systems Case Study Celera Genomics

1. Laboratory Automation & Instrumentation Power Protection Systems Case Study Celera Genomics

2. Celera’s Benefits Lower Operating Cost Increased Productivity Happier Investigators/Managers/Staff Higher Revenue & Investor Potential

3. The Lab and OperatingEnvironment Key challenges and issues: • Profitability in the laboratory and automation environments • On time delivery of reportable results • Overall customer satisfaction • Internal and external

4. The Lab and OperatingEnvironment Key issues and distracters: • Instrumentation performance • Human Genome race • Availability and reliability • Environmental conditions

5. The Laboratory Key issues - Environmental: • Quality of power from the utility • Other equipment sharing the line • Centrifuges • Auto loaders / robotics • Pumps and heaters • Bar code readers (lasers) • Other PCR-DNA Sequencing Instrumentation

6. The Laboratory Quality of power directly from the utility: Desired waveform

7. The Laboratory The reality of laboratory and production power: Harmonic distortion and frequency variation waveform is typical

8. The Lab and OperatingEnvironment Key issues - Environmental: • Challenges for a Laboratory Productivity-Protection System (LPS) • Each application must be qualified • Peak loads • Other instrumentation line interference (transient) • Inrush currents and load (Power) factors • Power connection and distribution • Waveform (Volts, Hz, harmonic distortion, et al)

9. Franek Technologies, Inc. (FTI) The Leader in Power Protection for Medical and Scientific Instrumentation

10. Applications • Automation • Biotechnology • Drug discovery • DNA, human Genomics and Proteomics research • Pharmaceutical production • Clinical chemistry • Diagnostic imaging • Immunology and cytometry • Oncology • Hematology and blood banking • FDA 510(k) patient contact applications • Forensics • Scientific research • Other commercial laboratory instrumentation

11. Key Applications Several Billions in Protected Laboratory and Production Instrumentation • Baxter Healthcare • Over 1,800 LPS placements worldwide • Celera Genomics • 320 LPS placements in a single Lab • Mallinckrodt (Nellcor / Puritan-Bennett) • Over 200 FDA 510(k) Ventilator support – patient contact

12. Key Applications Several Billions in Protected Laboratory Instrumentation • Perkin Elmer / ABI, DNA & Protein Analyzers • Over 3,000 LPS placements worldwide • Datex Ohmeda, Drager and North American Drager • Over 200 510(k) LPS units for anesthesia work stations

13. Franek Value • Cutting Edge Technology • Engineered Qualified Application Program • Most Qualified and Experienced of all Power Protection Firms • Laboratory • Pharmaceutical • Healthcare Research • Scientific markets

14. LPS Economics “LPS Application Rules of Thumb” • LPS systems are very affordable • Service costs are $2,000 / Hr, or more • LPS systems have proven ROI • Instrumentation operating costs drop • Instrumentation availability is very high • Overall productivity is maximized • Instrumentation and internal customer satisfaction performance improves

15. FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Goals • First to patent the human genome – Time Critical Race Strategy: • Develop subscription based business to genome database • Partner with major pharmaceutical clients for drug discovery Challenges: • Maintain genome sequencing focus • Keep the Rockville, MD and Foster City, CA labs operational • Sequence in PE/ABI analyzers as development schedule required • Operate nearly 350 DNA Sequencer systems simultaneously

16. FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Laboratory Challenges and Issues • Keep the Rockville, MD and Foster City, CA labs operational • Sequence in PE/ABI analyzers as development schedule required • Operate nearly 350 DNA Sequencer systems simultaneously • Minimize laboratory infrastructure while maintaining effectiveness Strategy: • FTI Consulted as laboratory power engineering specialists • FTI’s five year partnership with PE/ABI lead to sole source orders Challenges: • LPS system design to assure DNA Sequencer operational integrity • LPS & Lab engineering modifications unique to the lab environment • Delivery and servicing of over 325 LPS units in 9 months

17. FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Celera and PE/ABI Results • Celera claimed victory in genome discovery • Kept Rockville, MD and Foster City, CA labs operational • Established PE/ABI and FTI as key business partners • Researchers provided FTI referrals to all lab types • CDC, NIH, University, Pharmaceutical, Forensic All economic goals for Celera and PE/ABI attained • Estimated savings for Celera at over $24 Million

18. FTI Case Studies Celera Genomics Corporation Detailed Analysis: FTI cost savings for Celera and PE/ABI (Goals) • Prevented .10 failure / instrument / 24 hour period (minimum) • 350 systems @ 365 days = 127,750 operational days • Potential operational incidents = 12,775 • Down time cost per incident $2,000.00 • Potential down time savings: $25,550,000 Benefit to Cost = 13:1

19. Engineered Laboratory Instrumentation Protection Systems www.franek-tech.com 800 326 6480 / + 1 714 734 5656