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Outline of Bioinorganic Chemistry. Chapter 1 Introduction Chapter 2 Alkali and Alkaline Earth Metals Chapter 3 Metalloproteins and Metalloenzymes Chapter 4 Bioinorganic Chemistry of Nonmetallic Inorganic Compounds Chapter 5 The Frontiers of Bioinorganic
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Outline of Bioinorganic Chemistry Chapter 1 Introduction Chapter 2 Alkali and Alkaline Earth Metals Chapter 3 Metalloproteins and Metalloenzymes Chapter 4 Bioinorganic Chemistry of Nonmetallic Inorganic Compounds Chapter 5 The Frontiers of Bioinorganic Chemistry
Chapter 1 Introduction 1. What is Bioinorganic Chemistry? 2. Inorganic Elements in Biological Systems 3. Biological Ligands (Biologically Important Compounds) 4. Experimental Methods (Physicochemical Methods and Biological Methods)
1.1 What is Bioinorganic Chemistry? 1.1.1 Bioinorganic Chemistry is a leading discipline at the interface of chemistry and biology • Many critical processes require metal ions, including respiration, much of metabolism, nitrogen fixation, photosynthesis, development, nerve transmission, muscle contraction, signal transduction, and protection against toxic and mutagenic agents. • Synthetic Chemists, Spectroscopists, Electrochemists, Theoreticians, Biochemists, and molecular Biologists meet at the frontiers of chemistry and biology and are challenged by exciting problems.
1.1.2 Development of Bioinorganic Chemistry Molecule, Cell, and Humanity elements small molecules amino acids, nucleotides,carbohydrates, fatty acids protein(enzymes), lipids, poly-carbohydrates poly-nucleotides metalloproteins (metalloenzymes), other macromolecules procaryocyte, eucaryocyte bacteria, microorganisms, plants, animals, humanity
The first symposium on bioinorganic chemistry was initiated by inorganic chemists in 1970 The first book called “ Bioinorganic Chemistry” was written by 45 authors and published in 1973
1.1.3 Current Situation Inorganic Biochemistry: An Introduction James A. Cowan The Ohio State University 1993, 1997 Principles of Bioinorganic Chemistry Stephen J. Lippard Maqssachusett Institute of Technology Jeremy M. Berg John Hopkins School of Medicine
The International Conference on Biological Inorganic Chemistry • 1983 in Florence, Italy • 1985 in the Algarve, Portugal • 1987 in Noordwijkerhout, The Netherlands • 1989 in Cambridge, USA • 1991 in Oxford, UK • 1993 in La Jolla, USA • 1995 in Lubeck, Germany • 1997 in Yokohama, Japan • 1999 in Minneapolis, Minnestoa
5th International Symposium on Applied Bioinorganic Chemistry • Metalloenzymes - Model Compounds • Biomaterials – Bioelectronics • Metal Based Drugs – Metals in Medicine • Metals Toxicology and Metals in the Environment • Metal Interaction with DNA and RNA Constituents • Spectroscopic Applications
J. Am. Chem. Soc • Biochemistry • Chem. Rev • Acc. Chem. Res. • Annual Reports on the Progress of Chemistry • Nature • Science • J. Inorg. Biochem
1.2 Inorganic Elements in Biological Systems • Bulk Elements: O, C, H, N, Ca, S, P, Na, K, Cl, Mg, etc. • Trace Elements: Mo, Mn, Fe, Co, Cu, Zn, I, Si, etc. • Ultra-trace Elements: V, Cr, Se, Br, Sn, F, etc.
1.3 Biological Ligands • Proteins, Carbohydrates, Lipid, Steroids, Nucleotides • Prosthetic Groups • Coenzyme B12 • Bleomycin and Siderophores • Complex Assembies
1.4 Methodology • Physicochemical Methods • Biological Methods Native, Modification, Mimesis Structure--Property--Function--Reaction; Structure--Property—Activity--Relationship
