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relative tissue and organ radiosensitivity n.
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Relative Tissue and Organ Radiosensitivity

Relative Tissue and Organ Radiosensitivity

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Relative Tissue and Organ Radiosensitivity

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  1. Relative Tissue and Organ Radiosensitivity

  2. TISSUE TYPES • Vegitative intermitotic tissue cells (VIMs) • Differentiating intermitotic cells (DIMs) • Multiple connective tissue cells (MCTs) • Reverting postmitotic cells (RPMs) • Fixed post mitotic cells (FPMs)

  3. Vegitative intermitotic tissue cells (VIMs) • Rapidly dividing, undifferentiated, have a short lifetime and are the most radiosensitive • Examples of VIMs are the basal cells of the epidermis and the crypt cells of the intestines

  4. Differentiating intermitotic cells (DIMs) • DIMs are produced by the division of VIMs; they are highly mitotic and relatively undifferentiated. DIMs are radiosensitive but not as much as VIMs • Example of a DIMs is type B spermatogonia

  5. Multiple connective tissue cells (MCTs) • Highly differentiated that still divide but not regularly • MCTs are comprised of endothelial cells (blood vessels) and fibroblasts (connective tissue) and are considered to be moderately radiosensitive

  6. Reverting postmitotic cells (RPMs) • Considered to be highly differentiated but are also long lived • These are the type of cells that the liver is made up of and are considered to be relatively radiosensitive

  7. Fixed post mitotic cells (FPMs) • Considered to be the most differentiated of all the tissue types and do not divide • These are the type of cells that make up nerves and are considered to be radioresistant

  8. Acutely responding organs • Organs that become easily inured by radiation shortly after exposure • They are easily injured because they are dependent on having a high degree of cellular proliferation • Examples of acutely responding organs are bone marrow, the gastrointestinal tract, skin, and testes

  9. Late-responding Organs • Complete opposite of acutely responding organs • The cells of these organs divide at a much slower rate • as a result injuries due to the exposure to radiation are not seen for long periods of time • Examples of late responding organs are the lungs and kidneys

  10. TEST • What are the five tissue type? • Vegitative intermitotic tissue cells (VIMs) • Differentiating intermitotic cells (DIMs) • Multiple connective tissue cells (MCTs) • Reverting postmitotic cells (RPMs) • Fixed post mitotic cells (FPMs)

  11. Which tissue type is the most radiosensitive? • Vegitative intermitotic tissue cells (VIMs)

  12. If an organ is injured shortly after receiving a dose of radiation, it is said to be: • An acutely responding organ

  13. Which tissue type is the most radioresistant and give one example. • Fixed post mitotic cells (FPMs), nerve cells

  14. Why are Fixed post mitotic cells (FPMs) radioresistant • They do not divide