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Overview of Immunity System: Innate and Adaptive Defense Mechanisms

This chapter, authored by Dr. Lien-Cheng Chen, delves into the immune system's complexities. It distinguishes between innate immunity, an immediate, non-specific defense against pathogens, and adaptive immunity, which offers specific, long-term responses that enhance memory upon repeated exposure. The text explains how macrophages play a vital role in innate immunity while lymphocytes are crucial for adaptive responses. It also highlights the importance of hematopoietic stem cells and cytokines in producing various immune cells, underscoring the system's intricate mechanisms of disease resistance.

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Overview of Immunity System: Innate and Adaptive Defense Mechanisms

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  1. Chapter 1 Immunity system 陳連城博士 (成大基礎醫學博士) 行政院衛生署藥物食品檢驗局 2009.2.27

  2. Innate immunity - A set of disease-resistance mechanisms that are not specific to a particular pathogen. - Respond immediately. It is the 1st line of defense during the critical period just after the host’s exposure to a pathogen. -macrophages

  3. Adaptive immunity • - Displays a high degree of specificity. • Occurs within 5 or 6 days after the initial • exposure to an Ag. • Exposure to the same Ag some time in the • future results in a memory response: • respond more quickly, stronger, and often • more effective in neutralizing and clearing • the pathogen. • - lymphocytes & Ab

  4. Hematopoietic stem cell (HSC) Pluripotent (self renewal): cytokines 1. T progenitor 2. B progenitor cytokines 1. T cell 2. B cell Lymphoid stem cell 1. Monocyte, macrophage, neutrophil 2. Eosinophil 3. Basophil 4. Erythrocyte 5. platelets 1. Granulocyte/monocyte progenitor 2. Eosinophil progenitor 3. Basophil progenitor 4. Erythroid progenitor 5. megakaryocyte cytokines cytokines Myeloid stem cell

  5. Figure 1-3

  6. Figure 1-7

  7. Figure 1-8 part 1 of 2

  8. Figure 1-9

  9. Figure 1-9 part 2 of 3

  10. Figure 1-10 part 1 of 2

  11. Figure 1-24

  12. Figure 1-32

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