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Quorum Sensing

Quorum Sensing . Do Bacteria feel,sense and talk?. لا لما نلم اصحابنا ا لاول. يلا ناكل. Under Supervision of : Prof.Dr / Nabil Hegazy Presented by : Elshimaa Ali Shrouk Mohamed . Talking Bacteria.

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Quorum Sensing

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  1. Quorum Sensing Do Bacteria feel,sense and talk? لا لما نلم اصحابنا الاول يلا ناكل Under Supervision of : Prof.Dr / Nabil Hegazy Presented by : Elshimaa Ali Shrouk Mohamed

  2. Talking Bacteria • Woody Hastings and co-workers in 1970 first described quorum sensing in the marine bacteria Vibriofischeri. Symbiotic relationship

  3. Cell density and quorum sensing

  4. Language Communication in Grouping

  5. QS controlled processes Biofilm formation conjugation motility

  6. Quorum Sensing in Nitrogen-Fixing Rhizobia Symbiotic relationship

  7. QS in Grame negative bacteria acyl-homoserine lactones (AHL)

  8. Great we talk the same language Different language

  9. private language of different species of bacteria

  10. Quorum quenching • Interference of AHL-dependent QS. Interference of AHL destroy AHLs SignallingConfusion (lactonase and acylase ) (oxidoreductases ) (hydrolysis)

  11. انا واخويا على ابن عمى وانا وابن عمى على الغريب bacteria produce QQ enzymes in competition for the limited natural resources. Ex (lactonases of B. thuringiensis has been shown to quench the virulence of the phytopathogenE. carotovora by inactivating its AHL signals) EX : pea and red alga produce compouds that interferance QS.

  12. Now a days most of bacteria are antibiotic resistant New way to control certain bacterial infections By QQ

  13. QS in Gram positive bacteria

  14. bacteria have 2 language (V. harveyi communication systems)

  15. Cholera at low cell density surprisingly it turn on all of its vierulence genes. then at a high cell density when autoinducers accumulate cholera turn off virulence.

  16. Biofilm formation relies quorum sensing Biofilm

  17. Biofilms are found almost everywhere in nature, including rivers, lakes, soil, water pipes, and even inside the human body. A common type of bacterial biofilm-responsible for plaque.

  18. References http://www.mendeley.com/catalog/synthetic-furanones-inhibit-quorum-sensing-enhance-bacterial-clearance-pseudomonas-aeruginosa-lung-i/ • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376616/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355433/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376616/ • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309046/#!po=2.72727

  19. تُسَبِّحُ لَهُ السَّمَاوَاتُ السَّبْعُ وَالأَرْضُ وَمَن فِيهِنَّ وَإِن مِّن شَيْءٍ إِلاَّ يُسَبِّحُ بِحَمْدَهِ وَلَـكِن لاَّ تَفْقَهُونَ تَسْبِيحَهُمْ إِنَّهُ كَانَ حَلِيماً غَفُوراً. [سورة الإسراء]

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